Immunomodulatory and neuroprotective effects of inosine

Adenosine has been considered as a potential immunomodulatory and neuroprotective agent for 30 years. Inosine, a major degradation product of adenosine, was thought originally to have no biological effects. However, recent studies demonstrate that inosine has potent immunomodulatory and neuroprotect...

Full description

Saved in:
Bibliographic Details
Published in:Trends in pharmacological sciences (Regular ed.) 2004-03, Vol.25 (3), p.152-157
Main Authors: Haskó, György, Sitkovsky, Michail V., Szabó, Csaba
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic
Animals
Humans
Hypoxia - drug therapy
Inosine - metabolism
Inosine - pharmacology
Neuroprotective Agents
Receptors, Cell Surface - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c449t-ef54cf758049724765abcbca30f1b56ec509e158c4fec89d0d1ce8ae4271ac843
cites cdi_FETCH-LOGICAL-c449t-ef54cf758049724765abcbca30f1b56ec509e158c4fec89d0d1ce8ae4271ac843
container_end_page 157
container_issue 3
container_start_page 152
container_title Trends in pharmacological sciences (Regular ed.)
container_volume 25
creator Haskó, György
Sitkovsky, Michail V.
Szabó, Csaba
description Adenosine has been considered as a potential immunomodulatory and neuroprotective agent for 30 years. Inosine, a major degradation product of adenosine, was thought originally to have no biological effects. However, recent studies demonstrate that inosine has potent immunomodulatory and neuroprotective effects. Inosine enhances mast-cell degranulation, attenuates the production of pro-inflammatory mediators by macrophages, lymphocytes and neutrophils, and is protective in animal models of sepsis, ischemia–reperfusion and autoimmunity. Inosine preserves the viability of glial cells and neuronal cells during hypoxia, and stimulates axonal regrowth after injury. The biological actions of inosine might involve effects on adenosine receptors, poly(ADP-ribose) polymerase and cellular energy levels. In this article, we review recent observations indicating that it might be possible to exploit inosine therapeutically for the treatment of tissue damage caused by inflammation and ischemia.
doi_str_mv 10.1016/j.tips.2004.01.006
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71735393</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165614704000239</els_id><sourcerecordid>17930401</sourcerecordid><originalsourceid>FETCH-LOGICAL-c449t-ef54cf758049724765abcbca30f1b56ec509e158c4fec89d0d1ce8ae4271ac843</originalsourceid><addsrcrecordid>eNqFkE1LxDAQhoMoun78AQ_Sk7fWmSZpWvAi4sfCghc9hzSdQpZtsyat4L83yy5409PM4Zl3Zh7GrhEKBKzu1sXktrEoAUQBWABUR2yBteI5V1wes0WCZF6hUGfsPMY1AHBe4ik7QwnYlAoXTC2HYR794Lt5YyYfvjMzdtlIc_Db4Ceyk_uijPo-dTHzfeZGH91Il-ykN5tIV4d6wT6en94fX_PV28vy8WGVWyGaKadeCtsrWYNoVClUJU1rW2s49NjKiqyEhlDWVqQFddNBh5ZqQyIdZ2wt-AW73eemaz5nipMeXLS02ZiR_By1wvQqb_i_IKqGgwBMYLkHbfAxBur1NrjBhG-NoHde9VrvvOqdVw2ok9c0dHNIn9uBut-Rg8gE3O8BSjK-HAUdraPRUudCUqc77_7K_wEP9Yni</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17930401</pqid></control><display><type>article</type><title>Immunomodulatory and neuroprotective effects of inosine</title><source>ScienceDirect Journals</source><creator>Haskó, György ; Sitkovsky, Michail V. ; Szabó, Csaba</creator><creatorcontrib>Haskó, György ; Sitkovsky, Michail V. ; Szabó, Csaba</creatorcontrib><description>Adenosine has been considered as a potential immunomodulatory and neuroprotective agent for 30 years. Inosine, a major degradation product of adenosine, was thought originally to have no biological effects. However, recent studies demonstrate that inosine has potent immunomodulatory and neuroprotective effects. Inosine enhances mast-cell degranulation, attenuates the production of pro-inflammatory mediators by macrophages, lymphocytes and neutrophils, and is protective in animal models of sepsis, ischemia–reperfusion and autoimmunity. Inosine preserves the viability of glial cells and neuronal cells during hypoxia, and stimulates axonal regrowth after injury. The biological actions of inosine might involve effects on adenosine receptors, poly(ADP-ribose) polymerase and cellular energy levels. In this article, we review recent observations indicating that it might be possible to exploit inosine therapeutically for the treatment of tissue damage caused by inflammation and ischemia.</description><identifier>ISSN: 0165-6147</identifier><identifier>EISSN: 1873-3735</identifier><identifier>DOI: 10.1016/j.tips.2004.01.006</identifier><identifier>PMID: 15019271</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adjuvants, Immunologic ; Animals ; Humans ; Hypoxia - drug therapy ; Inosine - metabolism ; Inosine - pharmacology ; Neuroprotective Agents ; Receptors, Cell Surface - drug effects</subject><ispartof>Trends in pharmacological sciences (Regular ed.), 2004-03, Vol.25 (3), p.152-157</ispartof><rights>2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-ef54cf758049724765abcbca30f1b56ec509e158c4fec89d0d1ce8ae4271ac843</citedby><cites>FETCH-LOGICAL-c449t-ef54cf758049724765abcbca30f1b56ec509e158c4fec89d0d1ce8ae4271ac843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15019271$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haskó, György</creatorcontrib><creatorcontrib>Sitkovsky, Michail V.</creatorcontrib><creatorcontrib>Szabó, Csaba</creatorcontrib><title>Immunomodulatory and neuroprotective effects of inosine</title><title>Trends in pharmacological sciences (Regular ed.)</title><addtitle>Trends Pharmacol Sci</addtitle><description>Adenosine has been considered as a potential immunomodulatory and neuroprotective agent for 30 years. Inosine, a major degradation product of adenosine, was thought originally to have no biological effects. However, recent studies demonstrate that inosine has potent immunomodulatory and neuroprotective effects. Inosine enhances mast-cell degranulation, attenuates the production of pro-inflammatory mediators by macrophages, lymphocytes and neutrophils, and is protective in animal models of sepsis, ischemia–reperfusion and autoimmunity. Inosine preserves the viability of glial cells and neuronal cells during hypoxia, and stimulates axonal regrowth after injury. The biological actions of inosine might involve effects on adenosine receptors, poly(ADP-ribose) polymerase and cellular energy levels. In this article, we review recent observations indicating that it might be possible to exploit inosine therapeutically for the treatment of tissue damage caused by inflammation and ischemia.</description><subject>Adjuvants, Immunologic</subject><subject>Animals</subject><subject>Humans</subject><subject>Hypoxia - drug therapy</subject><subject>Inosine - metabolism</subject><subject>Inosine - pharmacology</subject><subject>Neuroprotective Agents</subject><subject>Receptors, Cell Surface - drug effects</subject><issn>0165-6147</issn><issn>1873-3735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LxDAQhoMoun78AQ_Sk7fWmSZpWvAi4sfCghc9hzSdQpZtsyat4L83yy5409PM4Zl3Zh7GrhEKBKzu1sXktrEoAUQBWABUR2yBteI5V1wes0WCZF6hUGfsPMY1AHBe4ik7QwnYlAoXTC2HYR794Lt5YyYfvjMzdtlIc_Db4Ceyk_uijPo-dTHzfeZGH91Il-ykN5tIV4d6wT6en94fX_PV28vy8WGVWyGaKadeCtsrWYNoVClUJU1rW2s49NjKiqyEhlDWVqQFddNBh5ZqQyIdZ2wt-AW73eemaz5nipMeXLS02ZiR_By1wvQqb_i_IKqGgwBMYLkHbfAxBur1NrjBhG-NoHde9VrvvOqdVw2ok9c0dHNIn9uBut-Rg8gE3O8BSjK-HAUdraPRUudCUqc77_7K_wEP9Yni</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>Haskó, György</creator><creator>Sitkovsky, Michail V.</creator><creator>Szabó, Csaba</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20040301</creationdate><title>Immunomodulatory and neuroprotective effects of inosine</title><author>Haskó, György ; Sitkovsky, Michail V. ; Szabó, Csaba</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-ef54cf758049724765abcbca30f1b56ec509e158c4fec89d0d1ce8ae4271ac843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adjuvants, Immunologic</topic><topic>Animals</topic><topic>Humans</topic><topic>Hypoxia - drug therapy</topic><topic>Inosine - metabolism</topic><topic>Inosine - pharmacology</topic><topic>Neuroprotective Agents</topic><topic>Receptors, Cell Surface - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haskó, György</creatorcontrib><creatorcontrib>Sitkovsky, Michail V.</creatorcontrib><creatorcontrib>Szabó, Csaba</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in pharmacological sciences (Regular ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haskó, György</au><au>Sitkovsky, Michail V.</au><au>Szabó, Csaba</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunomodulatory and neuroprotective effects of inosine</atitle><jtitle>Trends in pharmacological sciences (Regular ed.)</jtitle><addtitle>Trends Pharmacol Sci</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>25</volume><issue>3</issue><spage>152</spage><epage>157</epage><pages>152-157</pages><issn>0165-6147</issn><eissn>1873-3735</eissn><abstract>Adenosine has been considered as a potential immunomodulatory and neuroprotective agent for 30 years. Inosine, a major degradation product of adenosine, was thought originally to have no biological effects. However, recent studies demonstrate that inosine has potent immunomodulatory and neuroprotective effects. Inosine enhances mast-cell degranulation, attenuates the production of pro-inflammatory mediators by macrophages, lymphocytes and neutrophils, and is protective in animal models of sepsis, ischemia–reperfusion and autoimmunity. Inosine preserves the viability of glial cells and neuronal cells during hypoxia, and stimulates axonal regrowth after injury. The biological actions of inosine might involve effects on adenosine receptors, poly(ADP-ribose) polymerase and cellular energy levels. In this article, we review recent observations indicating that it might be possible to exploit inosine therapeutically for the treatment of tissue damage caused by inflammation and ischemia.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>15019271</pmid><doi>10.1016/j.tips.2004.01.006</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0165-6147
ispartof Trends in pharmacological sciences (Regular ed.), 2004-03, Vol.25 (3), p.152-157
issn 0165-6147
1873-3735
language eng
recordid cdi_proquest_miscellaneous_71735393
source ScienceDirect Journals
subjects Adjuvants, Immunologic
Animals
Humans
Hypoxia - drug therapy
Inosine - metabolism
Inosine - pharmacology
Neuroprotective Agents
Receptors, Cell Surface - drug effects
title Immunomodulatory and neuroprotective effects of inosine
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T13%3A43%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Immunomodulatory%20and%20neuroprotective%20effects%20of%20inosine&rft.jtitle=Trends%20in%20pharmacological%20sciences%20(Regular%20ed.)&rft.au=Hask%C3%B3,%20Gy%C3%B6rgy&rft.date=2004-03-01&rft.volume=25&rft.issue=3&rft.spage=152&rft.epage=157&rft.pages=152-157&rft.issn=0165-6147&rft.eissn=1873-3735&rft_id=info:doi/10.1016/j.tips.2004.01.006&rft_dat=%3Cproquest_cross%3E17930401%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c449t-ef54cf758049724765abcbca30f1b56ec509e158c4fec89d0d1ce8ae4271ac843%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=17930401&rft_id=info:pmid/15019271&rfr_iscdi=true