The quantity of thyroid hormone in human milk is too low to influence plasma thyroid hormone levels in the very preterm infant

Summary background Thyroid hormone is crucial for brain development during foetal and neonatal life. In very preterm infants, transient low levels of plasma T4 and T3 are commonly found, a phenomenon referred to as transient hypothyroxinaemia of prematurity. We investigated whether breast milk is a...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2002-05, Vol.56 (5), p.621-627
Main Authors: Van Wassenaer, Aleid G., Stulp, Maykel R., Valianpour, Fredoen, Tamminga, Pieter, Ris Stalpers, Carrie, De Randamie, Janine S. E., Van Beusekom, Christien, De Vijlder, Jan J. M.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Breast Feeding
Endocrinopathies
Female
Humans
Infant, Newborn
Infant, Premature - blood
Iodine - analysis
Malignant tumors
Medical sciences
Milk, Human - chemistry
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Randomized Controlled Trials as Topic
Thyroid Hormones - analysis
Thyroid Hormones - blood
Thyroid. Thyroid axis (diseases)
Thyrotropin - analysis
Thyroxine - analysis
Thyroxine-Binding Proteins - analysis
Triiodothyronine - analysis
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Summary:Summary background Thyroid hormone is crucial for brain development during foetal and neonatal life. In very preterm infants, transient low levels of plasma T4 and T3 are commonly found, a phenomenon referred to as transient hypothyroxinaemia of prematurity. We investigated whether breast milk is a substantial resource of thyroid hormone for very preterm neonates and can alleviate transient hypothyroxinaemia. Both the influence of breast feeding on plasma thyroid hormone levels and the thyroid hormone concentration in preterm human milk were studied. methods Two groups were formed from the placebo group of a randomized thyroxine supplementation trial in infants born at
ISSN:0300-0664
1365-2265
DOI:10.1046/j.1365-2265.2002.01526.x