Mitochondria as the central control point of apoptosis

Mitochondria play a major role in apoptosis triggered by many stimuli. They integrate death signals through Bcl-2 family members and coordinate caspase activation through the release of cytochrome c as a result of the outer mitochondrial membrane becoming permeable. The mechanisms that lead to this...

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Bibliographic Details
Published in:Trends in Cell Biology 2000-09, Vol.10 (9), p.369-377
Main Authors: Desagher, Solange, Martinou, Jean-Claude
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis - physiology
Bax
Bcl-2
Capase
Cell death
Cytochrome c
HeLa Cells
Humans
Kinesin
Membrane structure
Mitochondria - physiology
Mitochondrion
Permeability transition pore (PTP)
Proto-Oncogene Proteins c-bcl-2 - physiology
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Summary:Mitochondria play a major role in apoptosis triggered by many stimuli. They integrate death signals through Bcl-2 family members and coordinate caspase activation through the release of cytochrome c as a result of the outer mitochondrial membrane becoming permeable. The mechanisms that lead to this permeability are not yet completely understood. Here, we attempt to summarize our current view of the mechanisms that lead to the efflux of many proteins from mitochondria during apoptosis and the role played by Bcl-2 family proteins in the control of this event.
ISSN:0962-8924
1879-3088
DOI:10.1016/S0962-8924(00)01803-1