Timing-Based LTP and LTD at Vertical Inputs to Layer II/III Pyramidal Cells in Rat Barrel Cortex

Experience-dependent plasticity in somatosensory (S1) and visual (V1) cortex involves rapid depression of responses to a deprived sensory input (a closed eye or a trimmed whisker). Such depression occurs first in layer II/III and may reflect plasticity at vertical inputs from layer IV to layer II/II...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2000-07, Vol.27 (1), p.45-56
Main Author: Feldman, Daniel E
Format: Article
Language:English
Subjects:
2-Amino-5-phosphonovalerate - pharmacology
Animals
cortex (barrel)
Electric Stimulation
Electrophysiology
Excitatory Amino Acid Antagonists - pharmacology
Excitatory Postsynaptic Potentials - drug effects
Excitatory Postsynaptic Potentials - physiology
Long-Term Potentiation - drug effects
Long-Term Potentiation - physiology
Membrane Potentials - drug effects
Membrane Potentials - physiology
Neuronal Plasticity - drug effects
Neuronal Plasticity - physiology
Patch-Clamp Techniques
Pyramidal Cells - drug effects
Pyramidal Cells - physiology
Rats
Rats, Long-Evans
Receptors, N-Methyl-D-Aspartate - drug effects
Receptors, N-Methyl-D-Aspartate - physiology
Somatosensory Cortex - cytology
Somatosensory Cortex - drug effects
Somatosensory Cortex - physiology
Synapses - physiology
Vibrissae - physiology
Vision, Monocular - physiology
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Summary:Experience-dependent plasticity in somatosensory (S1) and visual (V1) cortex involves rapid depression of responses to a deprived sensory input (a closed eye or a trimmed whisker). Such depression occurs first in layer II/III and may reflect plasticity at vertical inputs from layer IV to layer II/III pyramids. Here, I describe a timing-based, associative form of long-term potentiation and depression (LTP/LTD) at this synapse in S1. LTP occurred when excitatory postsynaptic potentials (EPSPs) led single postsynaptic action potentials (APs) within a narrow temporal window, and LTD occurred when APs led EPSPs within a significantly broader window. This long LTD window is unusual among timing-based learning rules and causes EPSPs that are uncorrelated with postsynaptic APs to become depressed. This behavior suggests a simple model for depression of deprived sensory responses in S1 and V1.
ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(00)00008-8