Effect of intracerebroventricular alpha -MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression

1  Program in Nutritional Sciences, Departments of 2  Psychiatry and Behavioral Sciences and 6  Medicine, University of Washington, Seattle 98195,  3  Puget Sound Veterans Affairs Health Care System, Seattle 98108,  7  Harborview Medical Center, Seattle, Washington 98104; 4  Department of Nutrition,...

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Bibliographic Details
Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2000-08, Vol.279 (2), p.695-R703
Main Authors: McMinn, Julie E, Wilkinson, Charles W, Havel, Peter J, Woods, Stephen C, Schwartz, Michael W
Format: Article
Language:English
Subjects:
Adipose Tissue - drug effects
alpha-MSH - administration & dosage
alpha-MSH - pharmacology
Animals
Blood - metabolism
Body Composition - drug effects
Body Weight - drug effects
Brain - metabolism
Eating - drug effects
In Situ Hybridization
Injections, Intraventricular
Male
Neuropeptides - genetics
Neuropeptides - metabolism
Proto-Oncogene Proteins c-fos - metabolism
Rats
Rats, Long-Evans
RNA, Messenger - metabolism
Time Factors
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Summary:1  Program in Nutritional Sciences, Departments of 2  Psychiatry and Behavioral Sciences and 6  Medicine, University of Washington, Seattle 98195,  3  Puget Sound Veterans Affairs Health Care System, Seattle 98108,  7  Harborview Medical Center, Seattle, Washington 98104; 4  Department of Nutrition, University of California at Davis, Davis, California 95616; and 5  Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45267 -Melanocyte-stimulating hormone ( -MSH) is a hypothalamic neuropeptide proposed to play a key role in energy homeostasis. To investigate the behavioral, metabolic, and hypothalamic responses to chronic central -MSH administration, -MSH was infused continuously into the third cerebral ventricle of rats for 6 days. Chronic -MSH infusion reduced cumulative food intake by 10.7% ( P  
ISSN:0363-6119
1522-1490
DOI:10.1152/ajpregu.2000.279.2.R695