Immunoregulatory T cells in tumor immunity

One mechanism of cancer immune evasion is the suppression of anti-tumor immunity by immunoregulatory T cells. Recent studies of these cells, especially CD4 +CD25 + T cells and NKT cells, have revealed molecular and cellular mechanisms of immunosuppression. Mouse studies have shown that either removi...

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Bibliographic Details
Published in:Current opinion in immunology 2004-04, Vol.16 (2), p.157-162
Main Authors: Terabe, Masaki, Berzofsky, Jay A
Format: Article
Language:English
Subjects:
Animals
Autoimmunity
CD4 Antigens - immunology
Humans
Immunologic Surveillance
Immunotherapy, Adoptive
Killer Cells, Natural - immunology
Mice
Mice, Knockout
Neoplasms - immunology
Receptors, Interleukin-2 - immunology
T-Lymphocytes - immunology
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Summary:One mechanism of cancer immune evasion is the suppression of anti-tumor immunity by immunoregulatory T cells. Recent studies of these cells, especially CD4 +CD25 + T cells and NKT cells, have revealed molecular and cellular mechanisms of immunosuppression. Mouse studies have shown that either removing immunoregulatory T cells or blocking an immunoregulatory pathway induced by such cells unmasks natural tumor immunosurveillance and improves responses to cancer vaccines. Studies of the corresponding T-cell populations in human cancer patients support a similar role for immunoregulatory T cells in immunosuppression, implying that blocking immunoregulatory T-cell activity might improve the efficacy of tumor vaccines or the immunotherapy of cancer.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2004.01.010