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Commercial and laboratory extracts from artichoke leaves: estimation of caffeoyl esters and flavonoidic compounds content
Artichoke leaf extracts are widely used alone or in association with other herbs for embittering alcoholic and soft drinks and to prepare herbal teas or herbal medicinal products. Despite this wide diffusion, the European Pharmacopoeia does not report an official method for the determination of the...
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| Published in: | Journal of pharmaceutical and biomedical analysis 2004-02, Vol.34 (2), p.349-357 |
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| Main Authors: | , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c504t-672077c9ec720b93c75e447ee3e7bcbb35369b69bc86d79a481bae0d5424a0a13 |
| container_end_page | 357 |
| container_issue | 2 |
| container_start_page | 349 |
| container_title | Journal of pharmaceutical and biomedical analysis |
| container_volume | 34 |
| creator | Mulinacci, N Prucher, D Peruzzi, M Romani, A Pinelli, P Giaccherini, C Vincieri, F.F |
| description | Artichoke leaf extracts are widely used alone or in association with other herbs for embittering alcoholic and soft drinks and to prepare herbal teas or herbal medicinal products. Despite this wide diffusion, the European Pharmacopoeia does not report an official method for the determination of the active principles of artichoke leaf extracts.
This work reports a quali-quantitative determination by HPLC/DAD and HPLC/MS techniques of both cynnamic acids and flavonoids present in some artichoke leaf commercial extracts (Com) compared with two different laboratory extracts (Lab). Most of the commercial extracts showed a similar quali-quantitative pattern with a single exception having five–six times higher value. The quantitative data from the Italian Pharmacopoeia(IP) official method does not evaluate the flavonoidic fraction and showed an overestimation of the caffeoyl esters with respect to the HPLC/DAD results. The proposed HPLC/DAD method was able to completely characterize and quantify this matrix and represents a contribution to better quality control of these herbal extracts. |
| doi_str_mv | 10.1016/S0731-7085(03)00552-1 |
| format | article |
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This work reports a quali-quantitative determination by HPLC/DAD and HPLC/MS techniques of both cynnamic acids and flavonoids present in some artichoke leaf commercial extracts (Com) compared with two different laboratory extracts (Lab). Most of the commercial extracts showed a similar quali-quantitative pattern with a single exception having five–six times higher value. The quantitative data from the Italian Pharmacopoeia(IP) official method does not evaluate the flavonoidic fraction and showed an overestimation of the caffeoyl esters with respect to the HPLC/DAD results. The proposed HPLC/DAD method was able to completely characterize and quantify this matrix and represents a contribution to better quality control of these herbal extracts.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/S0731-7085(03)00552-1</identifier><identifier>PMID: 15013149</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Analytical, structural and metabolic biochemistry ; Artichoke leaf extract ; Biological and medical sciences ; Caffeic acids ; Caffeic Acids - analysis ; Caffeic Acids - chemistry ; Chromatography, High Pressure Liquid - instrumentation ; Chromatography, High Pressure Liquid - methods ; Cynara scolymus ; Esters ; Flavonoids ; Flavonoids - analysis ; Flavonoids - chemistry ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; HPLC/DAD ; HPLC/MS ; Medical sciences ; Pharmacology. Drug treatments ; Plant Extracts - analysis ; Plant Extracts - chemistry ; Plant Leaves</subject><ispartof>Journal of pharmaceutical and biomedical analysis, 2004-02, Vol.34 (2), p.349-357</ispartof><rights>2003 Elsevier B.V.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-672077c9ec720b93c75e447ee3e7bcbb35369b69bc86d79a481bae0d5424a0a13</citedby><cites>FETCH-LOGICAL-c504t-672077c9ec720b93c75e447ee3e7bcbb35369b69bc86d79a481bae0d5424a0a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15475104$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15013149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mulinacci, N</creatorcontrib><creatorcontrib>Prucher, D</creatorcontrib><creatorcontrib>Peruzzi, M</creatorcontrib><creatorcontrib>Romani, A</creatorcontrib><creatorcontrib>Pinelli, P</creatorcontrib><creatorcontrib>Giaccherini, C</creatorcontrib><creatorcontrib>Vincieri, F.F</creatorcontrib><title>Commercial and laboratory extracts from artichoke leaves: estimation of caffeoyl esters and flavonoidic compounds content</title><title>Journal of pharmaceutical and biomedical analysis</title><addtitle>J Pharm Biomed Anal</addtitle><description>Artichoke leaf extracts are widely used alone or in association with other herbs for embittering alcoholic and soft drinks and to prepare herbal teas or herbal medicinal products. Despite this wide diffusion, the European Pharmacopoeia does not report an official method for the determination of the active principles of artichoke leaf extracts.
This work reports a quali-quantitative determination by HPLC/DAD and HPLC/MS techniques of both cynnamic acids and flavonoids present in some artichoke leaf commercial extracts (Com) compared with two different laboratory extracts (Lab). Most of the commercial extracts showed a similar quali-quantitative pattern with a single exception having five–six times higher value. The quantitative data from the Italian Pharmacopoeia(IP) official method does not evaluate the flavonoidic fraction and showed an overestimation of the caffeoyl esters with respect to the HPLC/DAD results. The proposed HPLC/DAD method was able to completely characterize and quantify this matrix and represents a contribution to better quality control of these herbal extracts.</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Artichoke leaf extract</subject><subject>Biological and medical sciences</subject><subject>Caffeic acids</subject><subject>Caffeic Acids - analysis</subject><subject>Caffeic Acids - chemistry</subject><subject>Chromatography, High Pressure Liquid - instrumentation</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Cynara scolymus</subject><subject>Esters</subject><subject>Flavonoids</subject><subject>Flavonoids - analysis</subject><subject>Flavonoids - chemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>HPLC/DAD</subject><subject>HPLC/MS</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - analysis</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Leaves</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqFkEurFDEQRoMo3vHqT1CyUXTRmkySTrcbkcEXXHChgrtQXV2N0XRnTDKD8-_NPFB3QiBFcfJV5TD2UIrnUsj2xSdhlWys6MxToZ4JYcy6kbfYSnZWNetWf73NVn-QK3Yv5--iUrLXd9mVNEIqqfsVO2ziPFNCD4HDMvIAQ0xQYjpw-lUSYMl8SnHmkIrHb_EH8UCwp_ySUy5-huLjwuPEEaaJ4iEc25TyKWwKsI9L9KNHjnHext0y5lothZZyn92ZIGR6cLmv2Ze3bz5v3jc3H9992Ly-adAIXZrWroW12BPWYugVWkNaWyJFdsBhUEa1_VAPdu1oe9CdHIDEaPRagwCprtmTc-42xZ-7up2bfUYKARaKu-ystDVPdxU0ZxBTzDnR5LapfjAdnBTu6NydnLujUCeUOzl3xwGPLgN2w0zj31cXyRV4fAEgI4QpwYI-_8Npa6TQlXt15qjq2HtKLqOnBWn0ibC4Mfr_rPIb1x6ghg</recordid><startdate>20040204</startdate><enddate>20040204</enddate><creator>Mulinacci, N</creator><creator>Prucher, D</creator><creator>Peruzzi, M</creator><creator>Romani, A</creator><creator>Pinelli, P</creator><creator>Giaccherini, C</creator><creator>Vincieri, F.F</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040204</creationdate><title>Commercial and laboratory extracts from artichoke leaves: estimation of caffeoyl esters and flavonoidic compounds content</title><author>Mulinacci, N ; Prucher, D ; Peruzzi, M ; Romani, A ; Pinelli, P ; Giaccherini, C ; Vincieri, F.F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-672077c9ec720b93c75e447ee3e7bcbb35369b69bc86d79a481bae0d5424a0a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Artichoke leaf extract</topic><topic>Biological and medical sciences</topic><topic>Caffeic acids</topic><topic>Caffeic Acids - analysis</topic><topic>Caffeic Acids - chemistry</topic><topic>Chromatography, High Pressure Liquid - instrumentation</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Cynara scolymus</topic><topic>Esters</topic><topic>Flavonoids</topic><topic>Flavonoids - analysis</topic><topic>Flavonoids - chemistry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>HPLC/DAD</topic><topic>HPLC/MS</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - analysis</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Leaves</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mulinacci, N</creatorcontrib><creatorcontrib>Prucher, D</creatorcontrib><creatorcontrib>Peruzzi, M</creatorcontrib><creatorcontrib>Romani, A</creatorcontrib><creatorcontrib>Pinelli, P</creatorcontrib><creatorcontrib>Giaccherini, C</creatorcontrib><creatorcontrib>Vincieri, F.F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mulinacci, N</au><au>Prucher, D</au><au>Peruzzi, M</au><au>Romani, A</au><au>Pinelli, P</au><au>Giaccherini, C</au><au>Vincieri, F.F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Commercial and laboratory extracts from artichoke leaves: estimation of caffeoyl esters and flavonoidic compounds content</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2004-02-04</date><risdate>2004</risdate><volume>34</volume><issue>2</issue><spage>349</spage><epage>357</epage><pages>349-357</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>Artichoke leaf extracts are widely used alone or in association with other herbs for embittering alcoholic and soft drinks and to prepare herbal teas or herbal medicinal products. Despite this wide diffusion, the European Pharmacopoeia does not report an official method for the determination of the active principles of artichoke leaf extracts.
This work reports a quali-quantitative determination by HPLC/DAD and HPLC/MS techniques of both cynnamic acids and flavonoids present in some artichoke leaf commercial extracts (Com) compared with two different laboratory extracts (Lab). Most of the commercial extracts showed a similar quali-quantitative pattern with a single exception having five–six times higher value. The quantitative data from the Italian Pharmacopoeia(IP) official method does not evaluate the flavonoidic fraction and showed an overestimation of the caffeoyl esters with respect to the HPLC/DAD results. The proposed HPLC/DAD method was able to completely characterize and quantify this matrix and represents a contribution to better quality control of these herbal extracts.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15013149</pmid><doi>10.1016/S0731-7085(03)00552-1</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0731-7085 |
| ispartof | Journal of pharmaceutical and biomedical analysis, 2004-02, Vol.34 (2), p.349-357 |
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| language | eng |
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| source | ScienceDirect Journals |
| subjects | Analysis Analytical, structural and metabolic biochemistry Artichoke leaf extract Biological and medical sciences Caffeic acids Caffeic Acids - analysis Caffeic Acids - chemistry Chromatography, High Pressure Liquid - instrumentation Chromatography, High Pressure Liquid - methods Cynara scolymus Esters Flavonoids Flavonoids - analysis Flavonoids - chemistry Fundamental and applied biological sciences. Psychology General pharmacology HPLC/DAD HPLC/MS Medical sciences Pharmacology. Drug treatments Plant Extracts - analysis Plant Extracts - chemistry Plant Leaves |
| title | Commercial and laboratory extracts from artichoke leaves: estimation of caffeoyl esters and flavonoidic compounds content |
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