Plasma thrombopoietin level after liver transplantation: relationship to cold ischemia time and coagulation parameters

To determine the relation between thrombopoietin (Tpo) levels following orthotopic liver transplantation (OLT), cold ischemia time and postoperative peripheral blood platelet count and prothrombin activity. Prospective clinical study. Intensive care unit. Fourteen patients with uncomplicated postope...

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Bibliographic Details
Published in:Intensive care medicine 2000-06, Vol.26 (6), p.804-807
Main Authors: DOBADO-BERRIOS, P. M, LOPEZ-PEDRERA, C, SORIANO, F, DE LA MATA, M, GUERRERO, R, TORRES, A, VELASCO, F
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Biological and medical sciences
Blood platelets
Cold
Cold Temperature
Enzymes
Female
Hepatitis
Humans
Immunoassay
Intensive care
Ischemia
Ischemia - pathology
Liver cirrhosis
Liver Transplantation
Liver, biliary tract, pancreas, portal circulation, spleen
Male
Medical sciences
Middle Aged
Organ Preservation
Plasma
Platelet Count
Prothrombin Time
Statistical significance
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Thrombocytopenia
Thrombopoietin - blood
Time Factors
Transplants & implants
Variance analysis
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Summary:To determine the relation between thrombopoietin (Tpo) levels following orthotopic liver transplantation (OLT), cold ischemia time and postoperative peripheral blood platelet count and prothrombin activity. Prospective clinical study. Intensive care unit. Fourteen patients with uncomplicated postoperative course after OLT. Plasma Tpo, as quantified by enzyme immunoassay, rose significantly from 194.9 +/- 45.7 pg/ml on day 1 after OLT to a peak value of 500.7 +/- 94.1 pg/ml on day 5 while platelet count was below normal values. Then the platelet count increased and reached normal values while Tpo decreased to normal. The rise of Tpo levels was associated with normalization of prothrombin time but peak Tpo concentrations were in inverse correlation with cold ischemia times. The extent of production of Tpo in the liver graft following OLT is affected by cold ischemia time. This observation may be applicable in the prevention of bleeding complications associated with postoperative thrombocytopenia.
ISSN:0342-4642
1432-1238
DOI:10.1007/s001340051251