Oncogenic Ras and its role in tumor cell invasion and metastasis

The processes by which cancer cells leave the tumor and enter adjacent tissue is known as invasion, whereas metastasis refers to secondary tumor colonization of tissue at a distance from the primary lesion. These two events are the most lethal of cancer phenomena and the signaling mechanisms that go...

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Bibliographic Details
Published in:Seminars in cancer biology 2004-04, Vol.14 (2), p.105-114
Main Authors: Campbell, Paul M, Der, Channing J
Format: Article
Language:English
Subjects:
Actins - metabolism
Animals
Cell Adhesion - genetics
Extracellular Matrix - metabolism
Gene Expression Regulation
Humans
Invasion
Metastasis
Mice
Mitogen-Activated Protein Kinases - metabolism
Monomeric GTP-Binding Proteins - metabolism
Neoplasm Invasiveness - genetics
Neoplasm Metastasis - genetics
Neovascularization, Pathologic - metabolism
Oncogene
Oncogene Protein p21(ras) - genetics
Oncogene Protein p21(ras) - metabolism
Oncogene Protein p21(ras) - physiology
Phosphatidylinositol 3-Kinases - metabolism
Proteins - metabolism
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-met
Ras
Receptors, Growth Factor
Response Elements - genetics
rho GTP-Binding Proteins - metabolism
Signal Transduction
Signaling
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Summary:The processes by which cancer cells leave the tumor and enter adjacent tissue is known as invasion, whereas metastasis refers to secondary tumor colonization of tissue at a distance from the primary lesion. These two events are the most lethal of cancer phenomena and the signaling mechanisms that govern them are complex. The Ras signaling pathways are well represented in their involvement in tumor initiation, but considerably less is known about their contribution to invasion and metastasis. In this review, we discuss the current evidence for mutant Ras proteins as significant players in these aspects of cancer progression.
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2003.09.015