Prognostic significance of DNA ploidy and proliferative index (MIB-1 index) in childhood rhabdomyosarcoma

The prognostic value of DNA ploidy and proliferative index (PI) are well established in many cancers, but their significance in childhood rhabdomyosarcoma (RMS) is unclear. We studied the DNA content and PI of 45 cases of childhood RMS obtained retrospectively. DNA histograms were hyperdiploid in 30...

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Bibliographic Details
Published in:American journal of clinical pathology 2004-03, Vol.121 (3), p.358-365
Main Authors: SAN MIGUEL-FRAILE, Pilar, CARRILLO-GIJON, Rosario, RODRIGUEZ-PERALTO, Jose Luis, BADIOLA, Iosu Anton
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Child
Child, Preschool
Diseases of the osteoarticular system
DNA, Neoplasm - genetics
Female
Humans
Infant
Infant, Newborn
Investigative techniques, diagnostic techniques (general aspects)
Ki-67 Antigen - metabolism
Male
Medical sciences
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Ploidies
Prognosis
Rhabdomyosarcoma - genetics
Rhabdomyosarcoma - metabolism
Rhabdomyosarcoma - mortality
Tumors of striated muscle and skeleton
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Summary:The prognostic value of DNA ploidy and proliferative index (PI) are well established in many cancers, but their significance in childhood rhabdomyosarcoma (RMS) is unclear. We studied the DNA content and PI of 45 cases of childhood RMS obtained retrospectively. DNA histograms were hyperdiploid in 30 cases (67%), diploid in 6 (13%), tetraploid in 5 (11%), polyploid in 3 (7%), and nonclassifiable in 1 (2%). The 5-year overall survival rate by ploidy was 60% (3/5) in tetraploid, 57% (17/30) in hyperdiploid, and 0% in diploid and polyploid cases (P = .000002). The 5-year overall survival by a PI less than or greater than 19% was 62% (13/21) and 21% (5/24), respectively (P = .006). In multivariate analysis, DNA ploidy (P = .001) was an important independent prognostic factor. DNA content in childhood RMS is an important variable in predicting prognosis. DNA hyperdiploid and tetraploid rhabdomyosarcomas had a favorable prognosis, while DNA diploid and polyploid tumors had a poor prognosis.
ISSN:0002-9173
1943-7722
DOI:10.1309/3dd80uc4ddj0jmt2