Autoimmunity in liver diseases

The characterization of B-cell epitopes using a variety of molecular biological tools has served to further a distinction between genuine autoimmune hepatitis and autoimmunity associated with ongoing viral hepatitis (Tables 1 and 2). This has been possible through the identification and characteriza...

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Bibliographic Details
Published in:Clinical reviews in allergy & immunology 2000-04, Vol.18 (2), p.127-140
Main Authors: STRASSBURG, Christian P, OBERMAYER-STRAUB, Petra, MANNS, Michael P
Format: Article
Language:English
Subjects:
Autoimmune Diseases - immunology
Autoimmune Diseases - physiopathology
Autoimmune Diseases - virology
Autoimmunity - immunology
Biological and medical sciences
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Hepatitis
Hepatitis D - immunology
Hepatitis D - physiopathology
Hepatitis D - virology
Hepatitis, Viral, Human - immunology
Hepatitis, Viral, Human - physiopathology
Hepatitis, Viral, Human - virology
Humans
Immunopathology
Liver Diseases - immunology
Liver Diseases - physiopathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Other diseases. Semiology
Polyendocrinopathies, Autoimmune - immunology
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Summary:The characterization of B-cell epitopes using a variety of molecular biological tools has served to further a distinction between genuine autoimmune hepatitis and autoimmunity associated with ongoing viral hepatitis (Tables 1 and 2). This has been possible through the identification and characterization of antibody reactivity with a number of antigens belonging to the the cytochrome P450 and UGT1A super families of proteins. As a short-term effect, these studies help to define the regimens of treatment--corticosteroids in genuine AIH, interferon in viral hepatitis--and thus contribute to treatment safety. From the collection of data available, it appears that HDV and HCV infection additionally may be model diseases for virus-associated autoimmunity in humans.[PUBLICATION ABSTRACT]
ISSN:1080-0549
1559-0267
1080-0549
DOI:10.1385/CRIAI:18:2:127