Efficacy and safety of selamectin against fleas on dogs and cats presented as veterinary patients in Europe

Two controlled and masked multi-centre studies were conducted to examine the efficacy of a novel topical avermectin, selamectin, against natural flea infestations on 418 dogs and 345 cats. Veterinary patients with viable flea infestations were enrolled in the studies, which were conducted in United...

Full description

Saved in:
Bibliographic Details
Published in:Veterinary parasitology 2000-08, Vol.91 (3), p.223-232
Main Authors: Benchaoui, H.A, Clemence, R.G, Clements, P.J.M, Jones, R.L, Watson, P, Shanks, D.J, Smith, D.G, Sture, G.H, Jernigan, A.D, Rowan, T.G
Format: Article
Language:English
Subjects:
Animals
Antiparasitic Agents - administration & dosage
Antiparasitic Agents - therapeutic use
avermectin
Avermectins
Cat Diseases - drug therapy
Cats
Ctenocephalides
Dog Diseases - drug therapy
Dogs
Drug Administration Schedule
Ectoparasitic Infestations - drug therapy
Ectoparasitic Infestations - veterinary
Europe
Female
Fleas
Housing, Animal
Ivermectin - analogs & derivatives
Ivermectin - therapeutic use
Male
Revolution
Selamectin
Siphonaptera - drug effects
Stronghold
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Two controlled and masked multi-centre studies were conducted to examine the efficacy of a novel topical avermectin, selamectin, against natural flea infestations on 418 dogs and 345 cats. Veterinary patients with viable flea infestations were enrolled in the studies, which were conducted in United Kingdom, France, Germany, and Italy. Animals were allocated randomly in a 2:1 ratio to one of two treatments: either selamectin alone at a minimum dosage of 6 mg kg −1 or fenthion at recommended dose rates. Concurrent use of an environmental spray (containing methoprene and either pyrethrins or permethrin) was permitted only for fenthion-treated animals. In-contact cats and dogs (animals living in the same home) received the same treatment as the first animal enrolled from the household, if recommended by the veterinarian. Study day 0 was defined as the day of first treatment. Animals were treated on days 0, 30, and 60, and flea comb counts and clinical evaluations were conducted on days 0, 14, 30, 60, and 90. Analysis of variance of ln(flea count+1) showed that values were significantly lower for selamectin alone compared with fenthion (with or without the concurrent use of an environmental spray) in dogs on days 30, 60, and 90 ( P
ISSN:0304-4017
1873-2550
DOI:10.1016/S0304-4017(00)00294-6