Characterization of the Human TBX20 Gene, a New Member of the T-Box Gene Family Closely Related to the Drosophila H15 Gene

T-box transcription factors contain a novel type of DNA-binding domain, the T-box domain, and are encoded by an ancient gene family. Four T-box genes, omb, Trg, org-1, and H15, have been identified in Drosophila, whereas in mammals the T-box gene family has expanded, and 12 human T-box genes have be...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 2000-08, Vol.67 (3), p.317-332
Main Authors: Meins, Moritz, Henderson, Deborah J., Bhattacharya, Shomi S., Sowden, Jane C.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Biological and medical sciences
Body Patterning
chromosome 7
Chromosomes, Human, Pair 7
DNA Primers - chemistry
Drosophila - genetics
Embryo, Mammalian - metabolism
Embryo, Nonmammalian
Extremities - embryology
Extremities - physiology
Eye - embryology
Eye - metabolism
Female
Fundamental and applied biological sciences. Psychology
Gene Expression
H15 gene
Heart - embryology
Humans
In Situ Hybridization - methods
Mice
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
Myocardium - metabolism
Pregnancy
Retinitis Pigmentosa - genetics
Reverse Transcriptase Polymerase Chain Reaction
Sequence Homology, Amino Acid
T-Box Domain Proteins - biosynthesis
T-Box Domain Proteins - genetics
TBX20 gene
Transcription. Transcription factor. Splicing. Rna processing
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Summary:T-box transcription factors contain a novel type of DNA-binding domain, the T-box domain, and are encoded by an ancient gene family. Four T-box genes, omb, Trg, org-1, and H15, have been identified in Drosophila, whereas in mammals the T-box gene family has expanded, and 12 human T-box genes have been isolated. We have identified a new human T-box gene, TBX20, and its mouse homologue Tbx20, which are more closely related to the Drosophila H15 gene than to any known vertebrate gene. H15 expression in leg imaginal discs correlates with commitment to a ventral fate, implicating this gene in early patterning events. We find that TBX20 is expressed in the fetal heart, eye, and limb, and during embryogenesis in the mouse, Tbx20 is expressed in the developing heart, eye, ventral neural tube, and limbs, indicating a possible role in regulating development of these tissues. The TBX20 gene maps to chromosome 7p14–p15. An association between TBX20 and loci for retinitis pigmentosa, RP9, and blepharophimosis syndrome, BPES, have been excluded.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.2000.6249