The role of Bruton's tyrosine kinase in B-cell development and function: a genetic perspective

Mutations in Bruton's tyrosine kinase (Btk) result in the B-cell immunodeficiencies X-linked agammaglobulinemia in humans and X-linked immunodeficiency in mice. These diseases are characterized by blocks in B-cell development at multiple stages and impaired function of residual mature B cells....

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Bibliographic Details
Published in:Immunological reviews 2000-06, Vol.175 (1), p.120-127
Main Authors: Satterthwaite, A B, Witte, O N
Format: Article
Language:English
Subjects:
Agammaglobulinemia - immunology
Animals
B-Lymphocytes - immunology
Cell Differentiation
Mice
Mice, Knockout
Mutation
Protein-Tyrosine Kinases - genetics
Protein-Tyrosine Kinases - physiology
Signal Transduction
Transgenes
X Chromosome - genetics
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Summary:Mutations in Bruton's tyrosine kinase (Btk) result in the B-cell immunodeficiencies X-linked agammaglobulinemia in humans and X-linked immunodeficiency in mice. These diseases are characterized by blocks in B-cell development at multiple stages and impaired function of residual mature B cells. This review focuses on a series of in vivo genetic studies that have begun to define the mechanism by which Btk regulates B-cell development and function. The functional interactions between Btk and other signaling molecules defined by this approach are more complex than initially appreciated from in vitro biochemical and cell culture studies.
ISSN:0105-2896
1600-065X
DOI:10.1111/j.1600-065x.2000.imr017504.x