Autoantibody screening in subacute cerebellar ataxia

In a retrospective study of 280 sera from patients presenting with cerebellar signs, seven of whom had proved positive for the typical paraneoplastic serum antibodies that were requested by the clinicians, raised concentrations of antibodies to voltage-gated calcium channels or to glutamic acid deca...

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Bibliographic Details
Published in:The Lancet (British edition) 2000-08, Vol.356 (9229), p.565-566
Main Authors: Trivedi, Rikin, Mundanthanam, George, Amyes, Elisabeth, Lang, Bethan, Vincent, Angela
Format: Article
Language:English
Subjects:
Autoantibodies - analysis
Biological and medical sciences
Brain
Calcium channels
Calcium Channels - immunology
Carcinoma, Small Cell - diagnosis
Carcinoma, Small Cell - immunology
Cerebellar Ataxia - immunology
Glutamate Decarboxylase - immunology
Humans
Immune system
Immunohistochemical methods
Immunological methods for diagnosis and exploration
Immunopathology
Lung cancer
Lung Neoplasms - diagnosis
Lung Neoplasms - immunology
Medical procedures
Medical research
Medical sciences
Medical screening
Nervous system involvement in other diseases. Miscellaneous
Neurology
Paraneoplastic Syndromes - immunology
Retrospective Studies
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Summary:In a retrospective study of 280 sera from patients presenting with cerebellar signs, seven of whom had proved positive for the typical paraneoplastic serum antibodies that were requested by the clinicians, raised concentrations of antibodies to voltage-gated calcium channels or to glutamic acid decarboxylase were detected in a further seven sera. Systematic screening for these and other antibodies in future cases should help in the diagnosis and management of the patients.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(00)02585-X