Rinderpest virus infection in primary bovine skin fibroblasts

Rinderpest virus (RPV) replicated to a high titre in primary bovine skin fibroblasts. The course of infection was similar to that seen in established cell lines. Virulent field virus grew at a faster rate than the fully attenuated vaccine strain of the virus. Virus antigen expression, as measured by...

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Bibliographic Details
Published in:Archives of virology 2000-01, Vol.145 (6), p.1231-1237
Main Authors: LUND, B. T, BARRETT, T
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
bovine skin fibroblasts
Cattle
Cell Line
Cells, Cultured
Cercopithecus aethiops
Fibroblasts - virology
Flow Cytometry
Fundamental and applied biological sciences. Psychology
Microbiology
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Rinderpest virus
Rinderpest virus - pathogenicity
Rinderpest virus - physiology
Skin - cytology
Skin - virology
Vaccines, Attenuated - virology
Vero Cells
Viral Proteins - metabolism
Virology
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Summary:Rinderpest virus (RPV) replicated to a high titre in primary bovine skin fibroblasts. The course of infection was similar to that seen in established cell lines. Virulent field virus grew at a faster rate than the fully attenuated vaccine strain of the virus. Virus antigen expression, as measured by FACScan analysis, correlated with the time course of infection for the two strains in cell cultures. Wild type virus, obtained directly from cattle, infected cells at a slower rate than virus passaged even once in primary bovine skin fibroblasts. This is the first report of a productive infection of primary bovine skin fibroblasts by wild type RPV.
ISSN:0304-8608
1432-8798
DOI:10.1007/s007050070122