In vivo functions of integrins: lessons from null mutations in mice

The integrin family ( Hynes, R.O., 1992. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69, 11–25) is composed of at least 24 heterodimers formed from eight β subunits and 18 α subunits. Thus far, mice expressing null mutations of seven of the eight β subunits and 13 of the...

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Bibliographic Details
Published in:Matrix Biology 2000-07, Vol.19 (3), p.203-209
Main Author: Sheppard, Dean
Format: Article
Language:English
Subjects:
Animals
Extracellular matrix
Humans
Integrin
Integrin beta Chains
Integrins - classification
Integrins - genetics
Integrins - physiology
Knockout mice
Mice
Mice, Knockout
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Summary:The integrin family ( Hynes, R.O., 1992. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69, 11–25) is composed of at least 24 heterodimers formed from eight β subunits and 18 α subunits. Thus far, mice expressing null mutations of seven of the eight β subunits and 13 of the 18 known α subunits have been generated, With only a few exceptions, the phenotypes of each of the knockout lines are quite distinct. Studies utilizing integrin knockout mice and cells derived from these mice have provided considerable and sometimes surprising insights into unique functions of individual members of this family.
ISSN:0945-053X
1569-1802
DOI:10.1016/S0945-053X(00)00065-2