Dedifferentiated chondrosarcoma: use of MRI to guide needle biopsy

AIM: To describe the use of MRI to identify and biopsy areas of dedifferentiation in patients with a suspected diagnosis of dedifferentiated chondrosarcoma. MATERIALS AND METHODS: Low-grade chondrosarcoma is characterized at magnetic resonance imaging (MRI) as having a lobulate, hyperintense appeara...

Full description

Saved in:
Bibliographic Details
Published in:Clinical radiology 2004-03, Vol.59 (3), p.268-272
Main Authors: Saifuddin, A, Mann, B.S, Mahroof, S, Pringle, J.A.S, Briggs, T.W.R, Cannon, S.R
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Biopsy, Needle - methods
Bone and Bones - pathology
Bone Neoplasms - pathology
Chondrosarcoma
Chondrosarcoma - pathology
Dedifferentiation
Diseases of the osteoarticular system
Female
Humans
Magnetic Resonance Imaging - methods
Male
Medical sciences
Middle Aged
MRI
Needle biopsy
Retrospective Studies
Tumors of striated muscle and skeleton
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:AIM: To describe the use of MRI to identify and biopsy areas of dedifferentiation in patients with a suspected diagnosis of dedifferentiated chondrosarcoma. MATERIALS AND METHODS: Low-grade chondrosarcoma is characterized at magnetic resonance imaging (MRI) as having a lobulate, hyperintense appearance on T2-weighted spin-echo sequences. T2-weighted MR images were assessed in 15 patients with a final pathological diagnosis of dedifferentiated chondrosarcoma for regions of atypical reduced signal intensity. Information regarding the site of ultrasound or computed tomography (CT)-guided biopsy was available in 10 cases. RESULTS: Nine patients were male and six female with a mean age of 60 years (range 25–77 years). The sites involved were the distal femur ( n=4), pelvis ( n=3), proximal femur ( n=4), femoral diaphysis ( n=1), proximal humerus ( n=2) and proximal tibia ( n=1). The dedifferentiated component consisted of osteosarcoma ( n=5), malignant fibrous histiocytoma ( n=6), spindle cell sarcoma ( n=1), leiomyosarcoma ( n=1) and pleomorphic sarcoma ( n=1). In 14 of the 15 cases, areas of lower signal intensity lacking in lobulation were identified. In nine of the 10 cases, biopsy site included such areas and yielded high-grade sarcoma. CONCLUSIONS: Dedifferentiation within chondrosarcoma may be identified on T2-weighted MRI as areas of reduced signal intensity. These areas should be the preferred site of biopsy.
ISSN:0009-9260
1365-229X
DOI:10.1016/j.crad.2003.08.009