Lower-Limb Hypoplasia Due to Intrauterine Infection with Herpes Simplex Virus Type 2: Possible Confusion with Intrauterine Varicella-Zoster Syndrome

A neonate with lower-limb hypoplasia, cutaneous scars, bilateral chorioretinitis, and multiple brain abnormalities is presented. Intrauterine herpes simplex virus type 2 (HSV-2) infection was established on the basis of serological testing of the mother and viral cultures of the child's cutaneo...

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Bibliographic Details
Published in:Clinical infectious diseases 2004-04, Vol.38 (7), p.e57-e62
Main Authors: Johansson, A.-B., Rassart, A., Blum, D., Van Beers, D., Liesnard, Corinne
Format: Article
Language:English
Subjects:
Adult
Brain - abnormalities
Chorioretinitis - etiology
Female
Herpes Simplex - physiopathology
Herpes Simplex - virology
Herpes simplex virus 2
Herpes Zoster - congenital
Herpes Zoster - physiopathology
Herpesvirus 2, Human
Humans
Infant, Newborn
Pregnancy
Pregnancy Complications, Infectious - virology
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Summary:A neonate with lower-limb hypoplasia, cutaneous scars, bilateral chorioretinitis, and multiple brain abnormalities is presented. Intrauterine herpes simplex virus type 2 (HSV-2) infection was established on the basis of serological testing of the mother and viral cultures of the child's cutaneous lesions, obtained soon after birth. This is, to the best of our knowledge, the first case of a patient with in utero-acquired HSV-2 infection presenting with a limb hypoplasia. It illustrates that, in addition to congenital varicella-zoster syndrome, HSV-2 infection should also be considered in patients presenting with limb hypoplasia.
ISSN:1058-4838
1537-6591
DOI:10.1086/382673