Enantioselective Guest Binding and Dynamic Resolution of Cationic Ruthenium Complexes by a Chiral Metal−Ligand Assembly

A supramolecular metal−ligand assembly encapsulates a variety of cationic half-sandwich ruthenium complexes. Due to the chirality of both host and guest, chiral recognition is observed with diastereomeric excesses up to 70%. The chiral cavity can be used to carry out a dynamic resolution of the rapi...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2004-03, Vol.126 (12), p.3674-3675
Main Authors: Fiedler, Dorothea, Leung, Dennis H, Bergman, Robert G, Raymond, Kenneth N
Format: Article
Language:English
Subjects:
Chemical reactivity
Chemistry
Exact sciences and technology
Organic chemistry
Reactivity and mechanisms
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Summary:A supramolecular metal−ligand assembly encapsulates a variety of cationic half-sandwich ruthenium complexes. Due to the chirality of both host and guest, chiral recognition is observed with diastereomeric excesses up to 70%. The chiral cavity can be used to carry out a dynamic resolution of the rapidly equilibrating enantiomers of the chiral organometallic guest.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja039225a