WEANING INDUCES AN INCREASE IN THE NUMBER OF SPECIFIC CYTOKINE-SECRETING INTESTINAL LYMPHOCYTES IN MICE

Intestinal immunity differs from systemic immunity in several aspects and is frequently studied separately. In this work we have analysed the frequency of mononuclear cells spontaneously secreting the cytokines IL-2, IL-4, IL-5, IL-6, IL-10, interferon gamma (IFN-γ) and tumour necrosis factor (TNF-α...

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Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Pa.), 2000-08, Vol.12 (8), p.1267-1270
Main Authors: Vázquez, E, Gil, A, Garcı́a-Olivares, E, Rueda, R
Format: Article
Language:English
Subjects:
Animals
Cytokines - metabolism
Cytokines - secretion
Intestines - growth & development
Intestines - immunology
Intestines - metabolism
Lymphocytes - metabolism
Lymphocytes - secretion
Male
Mice
Mice, Inbred BALB C
Peyer's Patches - immunology
Weaning
weaning/cytokine/ELISPOT/intestinal lymphocytes/mice
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Summary:Intestinal immunity differs from systemic immunity in several aspects and is frequently studied separately. In this work we have analysed the frequency of mononuclear cells spontaneously secreting the cytokines IL-2, IL-4, IL-5, IL-6, IL-10, interferon gamma (IFN-γ) and tumour necrosis factor (TNF-α), in Peyer's patches and lamina propria of small intestine in mice by enzyme linked immunosorbent spot (ELISPOT) during 1 month after weaning. We have found a high percentage of spontaneous Th1as well as Th2cytokine-secreting lymphocytes in both populations, Peyer's patches and lamina propria. An increase in the number of the lymphocytes secreting most of the studied cytokines, at 1 and 2 weeks after weaning, was also observed. These results suggest that the increase in the number of cytokine secreting lymphocytes may be one of the potential mechanisms involved in the development of the intestinal immune system at weaning.
ISSN:1043-4666
1096-0023
DOI:10.1006/cyto.2000.0706