Suppression of Immunoglobulin E-Mediated Anaphylactic Reaction by Alpinia Oxyphylla in Rats

Abstract We investigated the effect of Alpinia oxyphylla water extract (AOWE) on immunoglobulin E (IgE)-mediated anaphylaxis activated by anti-dinitrophenyl (DNP) IgE antibody. AOWE dose-dependently suppressed passive cutaneous anaphylaxis (PCA) when intraperitoneally or orally administered. On the...

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Bibliographic Details
Published in:Immunopharmacology and immunotoxicology 2000-01, Vol.22 (2), p.267-277
Main Authors: Kim, Sang-Hyun, Choi, Yong-Kil, Jeong, Hyun-Ja, Kang, Hyong-Uk, Moon, Goo, Shin, Tae-Yong, Kim, Hyung-Min
Format: Article
Language:English
Subjects:
Alpinia oxyphylla
Alpinia oxyphylla water extract
Anaphylactic reaction
Animals
Anti-dnitrophenyl IgE antibody
Histamine
Histamine Release - drug effects
Immunoglobulin E - metabolism
In Vitro Techniques
Male
Mast Cells - drug effects
Mast Cells - immunology
Passive Cutaneous Anaphylaxis - drug effects
Passive Cutaneous Anaphylaxis - immunology
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plants, Medicinal
Rats
Rats, Sprague-Dawley
Tumor Necrosis Factor-alpha - secretion
Tumor necrosis factor-α
Zingiberales
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Summary:Abstract We investigated the effect of Alpinia oxyphylla water extract (AOWE) on immunoglobulin E (IgE)-mediated anaphylaxis activated by anti-dinitrophenyl (DNP) IgE antibody. AOWE dose-dependently suppressed passive cutaneous anaphylaxis (PCA) when intraperitoneally or orally administered. On the other hand, it showed weak suppressive activity when administred intravenously. AOWE dose-dependently suppressed anaphylactic histamine release from rat peritoneal mast cells (RPMC) activated by anti-DNP IgE antibody. However, AOWE had a significant augmenting effect on anti-DNP IgE antibody-induced tumor necrosis factor-α secretion from RPMC. These results indicated that AOWE may possess strong antianaphylactic action and also suggest that differential activity following administration routes may be caused by difference of bioavailability.
ISSN:0892-3973
1532-2513
DOI:10.3109/08923970009016420