Ru(II)-Catalyzed Chemo- and Regioselective Cyclotrimerization of Three Unsymmetrical Alkynes through Boron Temporary Tether. One-Pot Four-Component Coupling via Cyclotrimerization/Suzuki−Miyaura Coupling

The Ru(II)-catalyzed [2+2+2] cyclotrimerization of alkynylboronates, propargyl alcohol, and terminal alkynes proceeded chemo- and regioselectively to give rise to arylboronates, which were subjected to Suzuki−Miyaura cross-coupling with aryliodides to afford highly substituted biaryls in 53−76% yiel...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2004-03, Vol.126 (12), p.3712-3713
Main Authors: Yamamoto, Yoshihiko, Ishii, Jun-ichi, Nishiyama, Hisao, Itoh, Kenji
Format: Article
Language:English
Subjects:
Chemical reactivity
Chemistry
Exact sciences and technology
Organic chemistry
Reactivity and mechanisms
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Summary:The Ru(II)-catalyzed [2+2+2] cyclotrimerization of alkynylboronates, propargyl alcohol, and terminal alkynes proceeded chemo- and regioselectively to give rise to arylboronates, which were subjected to Suzuki−Miyaura cross-coupling with aryliodides to afford highly substituted biaryls in 53−76% yields.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja049673y