Immune Regulation by Self-Reactive T Cells is Antigen Specific

Immune regulation plays an important role in the establishment and maintenance of self-tolerance. Nevertheless, it has been difficult to conclude whether regulation is Ag specific because studies have focused on polyclonal populations of regulatory T cells. We have used in this study a murine transg...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2004-04, Vol.172 (7), p.4285-4291
Main Authors: Tanchot, Corinne, Vasseur, Florence, Pontoux, Christiane, Garcia, Corinne, Sarukhan, Adelaida
Format: Article
Language:English
Subjects:
Animals
Autoantigens - genetics
Autoantigens - immunology
Bystander Effect - genetics
Bystander Effect - immunology
Cell Differentiation - genetics
Cell Differentiation - immunology
Cell Division - genetics
Cell Division - immunology
Cytokines - antagonists & inhibitors
Cytokines - biosynthesis
Epitopes, T-Lymphocyte - genetics
Epitopes, T-Lymphocyte - immunology
Interphase - genetics
Interphase - immunology
Mice
Mice, Inbred BALB C
Mice, Transgenic
Receptors, Antigen, T-Cell, alpha-beta - genetics
Receptors, Antigen, T-Cell, alpha-beta - physiology
Receptors, Interleukin-2 - biosynthesis
Ribonucleoproteins - genetics
Ribonucleoproteins - immunology
SS-B Antigen
T-Lymphocyte Subsets - cytology
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - metabolism
T-Lymphocytes, Helper-Inducer - cytology
T-Lymphocytes, Helper-Inducer - immunology
T-Lymphocytes, Helper-Inducer - metabolism
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Summary:Immune regulation plays an important role in the establishment and maintenance of self-tolerance. Nevertheless, it has been difficult to conclude whether regulation is Ag specific because studies have focused on polyclonal populations of regulatory T cells. We have used in this study a murine transgenic model that generates self-reactive, regulatory T cells of known Ag specificity to determine their capacity to suppress naive T cells specific for other Ags. We show that these regulatory cells can regulate the responses of naive T cells with the same TCR specificity, but do not inhibit T cell proliferation or differentiation of naive T cells specific for other Ags. These results demonstrate that immune regulation may be more Ag specific than previously proposed.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.172.7.4285