Micronutrients and Innate Immunity

Micronutrients such as zinc, selenium, iron, copper, β-carotene, vitamins A, C, and E, and folic acid can influence several components of innate immunity. Select micronutrients play an important role in alteration of oxidant-mediated tissue injury, and phagocytic cells produce reactive oxidants as p...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 2000-09, Vol.182 (Supplement-1), p.S5-S10
Main Authors: Erickson, Kent L., Medina, Edward A., Hubbard, Neil E.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cytokines
Deficiency Diseases - immunology
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Humans
Immunity
Innate immunity
Macrophages
Micronutrients
Natural killer cells
Neutrophils
Phagocytosis
Selenium
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamin C
Vitamins
Workshop Overview
Zinc
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c453t-89210cdaaea0a410a30ac8141ab5a58242efc9af2d15d799d2093ab124b779bc3
cites cdi_FETCH-LOGICAL-c453t-89210cdaaea0a410a30ac8141ab5a58242efc9af2d15d799d2093ab124b779bc3
container_end_page S10
container_issue Supplement-1
container_start_page S5
container_title The Journal of infectious diseases
container_volume 182
creator Erickson, Kent L.
Medina, Edward A.
Hubbard, Neil E.
description Micronutrients such as zinc, selenium, iron, copper, β-carotene, vitamins A, C, and E, and folic acid can influence several components of innate immunity. Select micronutrients play an important role in alteration of oxidant-mediated tissue injury, and phagocytic cells produce reactive oxidants as part of the defense against infectious agents. Thus, adequate micronutrients are required to prevent damage of cells participating in innate immunity. Deficiencies in zinc and vitamins A and D may reduce natural killer cell function, whereas supplemental zinc or vitamin C may enhance their activity. The specific effects of micronutrients on neutrophil functions are not clear. Select micronutrients may play a role in innate immunity associated with some disease processes. Future studies should focus on issues such as age-related micronutrient status and innate immunity, alterations of micronutrients in disease states and their effect on innate immunity, and the mechanisms by which micronutrients alter innate immunity.
doi_str_mv 10.1086/315922
format article
fullrecord <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_71758608</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>30109325</jstor_id><sourcerecordid>30109325</sourcerecordid><originalsourceid>FETCH-LOGICAL-c453t-89210cdaaea0a410a30ac8141ab5a58242efc9af2d15d799d2093ab124b779bc3</originalsourceid><addsrcrecordid>eNqF0EtrFEEUBeBCFDOJ-g-UIQF3rffWu5YSHzMQUUkEcVPcrq6GHqerY1U3mH9vhx5GcePqLs7HgXsYe4bwCsHq1wKV4_wBW6ESptIaxUO2AuC8QuvcCTstZQcAUmjzmJ0gOCmlsSt2_rELeUjTmLuYxrKm1Ky3KdEY19u-n1I33j1hj1ral_j0cM_Y1_fvbi431dWnD9vLN1dVkEqMlXUcITREkYAkAgmgYFEi1YqU5ZLHNjhqeYOqMc41HJygGrmsjXF1EGfs5dJ7m4efUyyj77sS4n5PKQ5T8QaNshrsfyGa-WUu-AzP_4G7YcppfsJzLhxY1PpP27xDKTm2_jZ3PeU7j-Dvt_XLtjN8cWib6j42f7FlzBlcHACVQPs2UwpdOTrnNNp79XxRuzIO-ZgKmHsEV3NeLXlXxvjrmFP-4bURRvnNt-9-c3N9LT7Lt_6L-A2dkZWr</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223908166</pqid></control><display><type>article</type><title>Micronutrients and Innate Immunity</title><source>Oxford Journals Online</source><source>JSTOR</source><creator>Erickson, Kent L. ; Medina, Edward A. ; Hubbard, Neil E.</creator><creatorcontrib>Erickson, Kent L. ; Medina, Edward A. ; Hubbard, Neil E.</creatorcontrib><description>Micronutrients such as zinc, selenium, iron, copper, β-carotene, vitamins A, C, and E, and folic acid can influence several components of innate immunity. Select micronutrients play an important role in alteration of oxidant-mediated tissue injury, and phagocytic cells produce reactive oxidants as part of the defense against infectious agents. Thus, adequate micronutrients are required to prevent damage of cells participating in innate immunity. Deficiencies in zinc and vitamins A and D may reduce natural killer cell function, whereas supplemental zinc or vitamin C may enhance their activity. The specific effects of micronutrients on neutrophil functions are not clear. Select micronutrients may play a role in innate immunity associated with some disease processes. Future studies should focus on issues such as age-related micronutrient status and innate immunity, alterations of micronutrients in disease states and their effect on innate immunity, and the mechanisms by which micronutrients alter innate immunity.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/315922</identifier><identifier>PMID: 10944478</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Biological and medical sciences ; Cytokines ; Deficiency Diseases - immunology ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Humans ; Immunity ; Innate immunity ; Macrophages ; Micronutrients ; Natural killer cells ; Neutrophils ; Phagocytosis ; Selenium ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin C ; Vitamins ; Workshop Overview ; Zinc</subject><ispartof>The Journal of infectious diseases, 2000-09, Vol.182 (Supplement-1), p.S5-S10</ispartof><rights>Copyright 2000 Infectious Diseases Society of America</rights><rights>2001 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Sep 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-89210cdaaea0a410a30ac8141ab5a58242efc9af2d15d799d2093ab124b779bc3</citedby><cites>FETCH-LOGICAL-c453t-89210cdaaea0a410a30ac8141ab5a58242efc9af2d15d799d2093ab124b779bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30109325$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30109325$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>309,310,314,777,781,786,787,23911,23912,25121,27905,27906,58219,58452</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=996188$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10944478$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erickson, Kent L.</creatorcontrib><creatorcontrib>Medina, Edward A.</creatorcontrib><creatorcontrib>Hubbard, Neil E.</creatorcontrib><title>Micronutrients and Innate Immunity</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>Micronutrients such as zinc, selenium, iron, copper, β-carotene, vitamins A, C, and E, and folic acid can influence several components of innate immunity. Select micronutrients play an important role in alteration of oxidant-mediated tissue injury, and phagocytic cells produce reactive oxidants as part of the defense against infectious agents. Thus, adequate micronutrients are required to prevent damage of cells participating in innate immunity. Deficiencies in zinc and vitamins A and D may reduce natural killer cell function, whereas supplemental zinc or vitamin C may enhance their activity. The specific effects of micronutrients on neutrophil functions are not clear. Select micronutrients may play a role in innate immunity associated with some disease processes. Future studies should focus on issues such as age-related micronutrient status and innate immunity, alterations of micronutrients in disease states and their effect on innate immunity, and the mechanisms by which micronutrients alter innate immunity.</description><subject>Biological and medical sciences</subject><subject>Cytokines</subject><subject>Deficiency Diseases - immunology</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Immunity</subject><subject>Innate immunity</subject><subject>Macrophages</subject><subject>Micronutrients</subject><subject>Natural killer cells</subject><subject>Neutrophils</subject><subject>Phagocytosis</subject><subject>Selenium</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin C</subject><subject>Vitamins</subject><subject>Workshop Overview</subject><subject>Zinc</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqF0EtrFEEUBeBCFDOJ-g-UIQF3rffWu5YSHzMQUUkEcVPcrq6GHqerY1U3mH9vhx5GcePqLs7HgXsYe4bwCsHq1wKV4_wBW6ESptIaxUO2AuC8QuvcCTstZQcAUmjzmJ0gOCmlsSt2_rELeUjTmLuYxrKm1Ky3KdEY19u-n1I33j1hj1ral_j0cM_Y1_fvbi431dWnD9vLN1dVkEqMlXUcITREkYAkAgmgYFEi1YqU5ZLHNjhqeYOqMc41HJygGrmsjXF1EGfs5dJ7m4efUyyj77sS4n5PKQ5T8QaNshrsfyGa-WUu-AzP_4G7YcppfsJzLhxY1PpP27xDKTm2_jZ3PeU7j-Dvt_XLtjN8cWib6j42f7FlzBlcHACVQPs2UwpdOTrnNNp79XxRuzIO-ZgKmHsEV3NeLXlXxvjrmFP-4bURRvnNt-9-c3N9LT7Lt_6L-A2dkZWr</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>Erickson, Kent L.</creator><creator>Medina, Edward A.</creator><creator>Hubbard, Neil E.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20000901</creationdate><title>Micronutrients and Innate Immunity</title><author>Erickson, Kent L. ; Medina, Edward A. ; Hubbard, Neil E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-89210cdaaea0a410a30ac8141ab5a58242efc9af2d15d799d2093ab124b779bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>Cytokines</topic><topic>Deficiency Diseases - immunology</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Immunity</topic><topic>Innate immunity</topic><topic>Macrophages</topic><topic>Micronutrients</topic><topic>Natural killer cells</topic><topic>Neutrophils</topic><topic>Phagocytosis</topic><topic>Selenium</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin C</topic><topic>Vitamins</topic><topic>Workshop Overview</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Erickson, Kent L.</creatorcontrib><creatorcontrib>Medina, Edward A.</creatorcontrib><creatorcontrib>Hubbard, Neil E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Erickson, Kent L.</au><au>Medina, Edward A.</au><au>Hubbard, Neil E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Micronutrients and Innate Immunity</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2000-09-01</date><risdate>2000</risdate><volume>182</volume><issue>Supplement-1</issue><spage>S5</spage><epage>S10</epage><pages>S5-S10</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Micronutrients such as zinc, selenium, iron, copper, β-carotene, vitamins A, C, and E, and folic acid can influence several components of innate immunity. Select micronutrients play an important role in alteration of oxidant-mediated tissue injury, and phagocytic cells produce reactive oxidants as part of the defense against infectious agents. Thus, adequate micronutrients are required to prevent damage of cells participating in innate immunity. Deficiencies in zinc and vitamins A and D may reduce natural killer cell function, whereas supplemental zinc or vitamin C may enhance their activity. The specific effects of micronutrients on neutrophil functions are not clear. Select micronutrients may play a role in innate immunity associated with some disease processes. Future studies should focus on issues such as age-related micronutrient status and innate immunity, alterations of micronutrients in disease states and their effect on innate immunity, and the mechanisms by which micronutrients alter innate immunity.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>10944478</pmid><doi>10.1086/315922</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0022-1899
ispartof The Journal of infectious diseases, 2000-09, Vol.182 (Supplement-1), p.S5-S10
issn 0022-1899
1537-6613
language eng
recordid cdi_proquest_miscellaneous_71758608
source Oxford Journals Online; JSTOR
subjects Biological and medical sciences
Cytokines
Deficiency Diseases - immunology
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Humans
Immunity
Innate immunity
Macrophages
Micronutrients
Natural killer cells
Neutrophils
Phagocytosis
Selenium
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamin C
Vitamins
Workshop Overview
Zinc
title Micronutrients and Innate Immunity
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T17%3A47%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Micronutrients%20and%20Innate%20Immunity&rft.jtitle=The%20Journal%20of%20infectious%20diseases&rft.au=Erickson,%20Kent%20L.&rft.date=2000-09-01&rft.volume=182&rft.issue=Supplement-1&rft.spage=S5&rft.epage=S10&rft.pages=S5-S10&rft.issn=0022-1899&rft.eissn=1537-6613&rft.coden=JIDIAQ&rft_id=info:doi/10.1086/315922&rft_dat=%3Cjstor_proqu%3E30109325%3C/jstor_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c453t-89210cdaaea0a410a30ac8141ab5a58242efc9af2d15d799d2093ab124b779bc3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=223908166&rft_id=info:pmid/10944478&rft_jstor_id=30109325&rfr_iscdi=true