Mini-review: gephyrin, a major postsynaptic protein of GABAergic synapses

gamma-aminobutyric acid type A (GABAA) receptors are located at the majority of inhibitory synapses in the mammalian brain. However, the mechanisms by which GABAA receptor subunits are targeted to, and clustered in, the postsynaptic membrane are poorly understood. Recent studies have demonstrated th...

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Bibliographic Details
Published in:The European journal of neuroscience 2000-07, Vol.12 (7), p.2205-2210
Main Authors: Sassoè-Pognetto, M, Fritschy, J M
Format: Article
Language:English
Subjects:
Animals
Carrier Proteins - physiology
gamma-Aminobutyric Acid - physiology
Membrane Proteins - physiology
Receptors, GABA-A - physiology
Synapses - chemistry
Synapses - physiology
Online Access:Get full text
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Summary:gamma-aminobutyric acid type A (GABAA) receptors are located at the majority of inhibitory synapses in the mammalian brain. However, the mechanisms by which GABAA receptor subunits are targeted to, and clustered in, the postsynaptic membrane are poorly understood. Recent studies have demonstrated that gephyrin, a protein first identified as a component of the glycine receptor (GlyR) complex, is colocalized with several subtypes of GABAA receptors and is involved in the stabilization of postsynaptic GABAA receptor clusters. Thus, gephyrin functions as a clustering protein for major subtypes of inhibitory ion channel receptors.
ISSN:0953-816X
1460-9568