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The Drosophila SDE3 Homolog armitage Is Required for oskar mRNA Silencing and Embryonic Axis Specification
Polarization of the microtubule cytoskeleton during early oogenesis is required to specify the posterior of the Drosophila oocyte, which is essential for asymmetric mRNA localization during mid-oogenesis and for embryonic axis specification. The posterior determinant oskar mRNA is translationally si...
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| Published in: | Cell 2004-03, Vol.116 (6), p.817-829 |
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| creator | Cook, Heather A Koppetsch, Birgit S Wu, Jing Theurkauf, William E |
| description | Polarization of the microtubule cytoskeleton during early oogenesis is required to specify the posterior of the
Drosophila oocyte, which is essential for asymmetric mRNA localization during mid-oogenesis and for embryonic axis specification. The posterior determinant
oskar mRNA is translationally silent until mid-oogenesis. We show that mutations in
armitage and three components of the RNAi pathway disrupt
oskar mRNA translational silencing, polarization of the microtubule cytoskeleton, and posterior localization of
oskar mRNA.
armitage encodes a homolog of SDE3, a presumptive RNA helicase involved in posttranscriptional gene silencing (RNAi) in
Arabidopsis, and is required for RNAi in
Drosophila ovaries. Armitage forms an asymmetric network associated with the polarized microtubule cytoskeleton and is concentrated with translationally silent
oskar mRNA in the oocyte. We conclude that RNA silencing is essential for establishment of the cytoskeletal polarity that initiates embryonic axis specification and for translational control of
oskar mRNA. |
| doi_str_mv | 10.1016/S0092-8674(04)00250-8 |
| format | article |
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Drosophila oocyte, which is essential for asymmetric mRNA localization during mid-oogenesis and for embryonic axis specification. The posterior determinant
oskar mRNA is translationally silent until mid-oogenesis. We show that mutations in
armitage and three components of the RNAi pathway disrupt
oskar mRNA translational silencing, polarization of the microtubule cytoskeleton, and posterior localization of
oskar mRNA.
armitage encodes a homolog of SDE3, a presumptive RNA helicase involved in posttranscriptional gene silencing (RNAi) in
Arabidopsis, and is required for RNAi in
Drosophila ovaries. Armitage forms an asymmetric network associated with the polarized microtubule cytoskeleton and is concentrated with translationally silent
oskar mRNA in the oocyte. We conclude that RNA silencing is essential for establishment of the cytoskeletal polarity that initiates embryonic axis specification and for translational control of
oskar mRNA.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/S0092-8674(04)00250-8</identifier><identifier>PMID: 15035984</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amino Acid Sequence - genetics ; Animals ; Arabidopsis Proteins - genetics ; Base Sequence - genetics ; Body Patterning - genetics ; Cell Polarity - genetics ; Cytoskeleton - genetics ; Cytoskeleton - metabolism ; DNA, Complementary - analysis ; DNA, Complementary - genetics ; Drosophila melanogaster ; Drosophila melanogaster - embryology ; Drosophila melanogaster - genetics ; Drosophila melanogaster - metabolism ; Drosophila Proteins - genetics ; Drosophila Proteins - isolation & purification ; Embryo, Nonmammalian - cytology ; Embryo, Nonmammalian - embryology ; Embryo, Nonmammalian - metabolism ; Female ; Microtubules - genetics ; Microtubules - metabolism ; Molecular Sequence Data ; Mutation ; Oocytes - cytology ; Oocytes - metabolism ; Protein Biosynthesis - genetics ; RNA Helicases - genetics ; RNA Helicases - isolation & purification ; RNA Interference - physiology</subject><ispartof>Cell, 2004-03, Vol.116 (6), p.817-829</ispartof><rights>2004 Cell Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-468512f8915c50f22b1ec48cbb524ea862e957e9c9f31976e523023b86e7d4af3</citedby><cites>FETCH-LOGICAL-c505t-468512f8915c50f22b1ec48cbb524ea862e957e9c9f31976e523023b86e7d4af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0092867404002508$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,45780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15035984$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cook, Heather A</creatorcontrib><creatorcontrib>Koppetsch, Birgit S</creatorcontrib><creatorcontrib>Wu, Jing</creatorcontrib><creatorcontrib>Theurkauf, William E</creatorcontrib><title>The Drosophila SDE3 Homolog armitage Is Required for oskar mRNA Silencing and Embryonic Axis Specification</title><title>Cell</title><addtitle>Cell</addtitle><description>Polarization of the microtubule cytoskeleton during early oogenesis is required to specify the posterior of the
Drosophila oocyte, which is essential for asymmetric mRNA localization during mid-oogenesis and for embryonic axis specification. The posterior determinant
oskar mRNA is translationally silent until mid-oogenesis. We show that mutations in
armitage and three components of the RNAi pathway disrupt
oskar mRNA translational silencing, polarization of the microtubule cytoskeleton, and posterior localization of
oskar mRNA.
armitage encodes a homolog of SDE3, a presumptive RNA helicase involved in posttranscriptional gene silencing (RNAi) in
Arabidopsis, and is required for RNAi in
Drosophila ovaries. Armitage forms an asymmetric network associated with the polarized microtubule cytoskeleton and is concentrated with translationally silent
oskar mRNA in the oocyte. We conclude that RNA silencing is essential for establishment of the cytoskeletal polarity that initiates embryonic axis specification and for translational control of
oskar mRNA.</description><subject>Amino Acid Sequence - genetics</subject><subject>Animals</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Base Sequence - genetics</subject><subject>Body Patterning - genetics</subject><subject>Cell Polarity - genetics</subject><subject>Cytoskeleton - genetics</subject><subject>Cytoskeleton - metabolism</subject><subject>DNA, Complementary - analysis</subject><subject>DNA, Complementary - genetics</subject><subject>Drosophila melanogaster</subject><subject>Drosophila melanogaster - embryology</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drosophila melanogaster - metabolism</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - isolation & purification</subject><subject>Embryo, Nonmammalian - cytology</subject><subject>Embryo, Nonmammalian - embryology</subject><subject>Embryo, Nonmammalian - metabolism</subject><subject>Female</subject><subject>Microtubules - genetics</subject><subject>Microtubules - metabolism</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>Oocytes - cytology</subject><subject>Oocytes - metabolism</subject><subject>Protein Biosynthesis - genetics</subject><subject>RNA Helicases - genetics</subject><subject>RNA Helicases - isolation & purification</subject><subject>RNA Interference - physiology</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqFkVFrFDEQx4Mo9qx-BCVPUh9WJ9lkkzzJ0V5toSj06nPIZmfb1N3NNdkT--2b8w59LAwMDL-Zgd-fkPcMPjNgzZc1gOGVbpQ4AfEJgEuo9AuyYGBUJZjiL8niH3JE3uR8DwBaSvmaHDEJtTRaLMj9zR3SsxRz3NyFwdH12aqmF3GMQ7ylLo1hdrdILzO9xodtSNjRPiYa8y-X6Hj9fUnXYcDJh6nQU0dXY5se4xQ8Xf4Jma436EMfvJtDnN6SV70bMr479GPy83x1c3pRXf34dnm6vKq8BDlXotGS8V4bJsug57xl6IX2bSu5QKcbjkYqNN70NTOqQclr4HWrG1SdcH19TD7u725SfNhinu0YssdhcBPGbbaKKWmkEM-CTBleRKoCyj3oi6icsLebFEaXHi0Du0vD_k3D7lRbKLVLw-qy9-HwYNuO2P3fOugvwNc9gMXH74DJZh-KTuyKaj_bLoZnXjwBhAeYhA</recordid><startdate>20040319</startdate><enddate>20040319</enddate><creator>Cook, Heather A</creator><creator>Koppetsch, Birgit S</creator><creator>Wu, Jing</creator><creator>Theurkauf, William E</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20040319</creationdate><title>The Drosophila SDE3 Homolog armitage Is Required for oskar mRNA Silencing and Embryonic Axis Specification</title><author>Cook, Heather A ; Koppetsch, Birgit S ; Wu, Jing ; Theurkauf, William E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-468512f8915c50f22b1ec48cbb524ea862e957e9c9f31976e523023b86e7d4af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Amino Acid Sequence - genetics</topic><topic>Animals</topic><topic>Arabidopsis Proteins - genetics</topic><topic>Base Sequence - genetics</topic><topic>Body Patterning - genetics</topic><topic>Cell Polarity - genetics</topic><topic>Cytoskeleton - genetics</topic><topic>Cytoskeleton - metabolism</topic><topic>DNA, Complementary - analysis</topic><topic>DNA, Complementary - genetics</topic><topic>Drosophila melanogaster</topic><topic>Drosophila melanogaster - embryology</topic><topic>Drosophila melanogaster - genetics</topic><topic>Drosophila melanogaster - metabolism</topic><topic>Drosophila Proteins - genetics</topic><topic>Drosophila Proteins - isolation & purification</topic><topic>Embryo, Nonmammalian - cytology</topic><topic>Embryo, Nonmammalian - embryology</topic><topic>Embryo, Nonmammalian - metabolism</topic><topic>Female</topic><topic>Microtubules - genetics</topic><topic>Microtubules - metabolism</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>Oocytes - cytology</topic><topic>Oocytes - metabolism</topic><topic>Protein Biosynthesis - genetics</topic><topic>RNA Helicases - genetics</topic><topic>RNA Helicases - isolation & purification</topic><topic>RNA Interference - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cook, Heather A</creatorcontrib><creatorcontrib>Koppetsch, Birgit S</creatorcontrib><creatorcontrib>Wu, Jing</creatorcontrib><creatorcontrib>Theurkauf, William E</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cook, Heather A</au><au>Koppetsch, Birgit S</au><au>Wu, Jing</au><au>Theurkauf, William E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Drosophila SDE3 Homolog armitage Is Required for oskar mRNA Silencing and Embryonic Axis Specification</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>2004-03-19</date><risdate>2004</risdate><volume>116</volume><issue>6</issue><spage>817</spage><epage>829</epage><pages>817-829</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>Polarization of the microtubule cytoskeleton during early oogenesis is required to specify the posterior of the
Drosophila oocyte, which is essential for asymmetric mRNA localization during mid-oogenesis and for embryonic axis specification. The posterior determinant
oskar mRNA is translationally silent until mid-oogenesis. We show that mutations in
armitage and three components of the RNAi pathway disrupt
oskar mRNA translational silencing, polarization of the microtubule cytoskeleton, and posterior localization of
oskar mRNA.
armitage encodes a homolog of SDE3, a presumptive RNA helicase involved in posttranscriptional gene silencing (RNAi) in
Arabidopsis, and is required for RNAi in
Drosophila ovaries. Armitage forms an asymmetric network associated with the polarized microtubule cytoskeleton and is concentrated with translationally silent
oskar mRNA in the oocyte. We conclude that RNA silencing is essential for establishment of the cytoskeletal polarity that initiates embryonic axis specification and for translational control of
oskar mRNA.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15035984</pmid><doi>10.1016/S0092-8674(04)00250-8</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | Amino Acid Sequence - genetics Animals Arabidopsis Proteins - genetics Base Sequence - genetics Body Patterning - genetics Cell Polarity - genetics Cytoskeleton - genetics Cytoskeleton - metabolism DNA, Complementary - analysis DNA, Complementary - genetics Drosophila melanogaster Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - isolation & purification Embryo, Nonmammalian - cytology Embryo, Nonmammalian - embryology Embryo, Nonmammalian - metabolism Female Microtubules - genetics Microtubules - metabolism Molecular Sequence Data Mutation Oocytes - cytology Oocytes - metabolism Protein Biosynthesis - genetics RNA Helicases - genetics RNA Helicases - isolation & purification RNA Interference - physiology |
| title | The Drosophila SDE3 Homolog armitage Is Required for oskar mRNA Silencing and Embryonic Axis Specification |
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