Diet-induced obesity in the rat: A model for gestational diabetes mellitus

Obesity is one of the most important risk factors for the development of gestational diabetes mellitus (GDM). However, in obese women, it is difficult to disentangle the genetic and environmental contributions. The aim of this study was to investigate whether diet-induced obesity results in GDM in r...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2004-03, Vol.190 (3), p.858-865
Main Authors: Holemans, Kathleen, Caluwaerts, Silvia, Poston, Lucilla, Van Assche, F.André
Format: Article
Language:English
Subjects:
Animal models
Animals
Biological and medical sciences
Body Composition
Body Weight
Cafeteria diet
Diabetes, Gestational
Diet - adverse effects
Disease Models, Animal
Female
Fetal Weight
Fetus - physiology
Gestational diabetes
Glucose Tolerance Test
Gynecology. Andrology. Obstetrics
Insulin Resistance
Medical sciences
Metabolic diseases
Obesity
Obesity - blood
Obesity - etiology
Obesity - pathology
Obesity - physiopathology
Pregnancy
Rat
Rats
Rats, Wistar
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Summary:Obesity is one of the most important risk factors for the development of gestational diabetes mellitus (GDM). However, in obese women, it is difficult to disentangle the genetic and environmental contributions. The aim of this study was to investigate whether diet-induced obesity results in GDM in rats with the same genetic background. Female Wistar rats were fed a cafeteria-style diet (CAF) or the standard control (C) diet from 70 days of age onward. After 4 weeks on the diets, subgroups of CAF and C rats were mated. In virgin and late-pregnant CAF and C rats, we determined body weight, body composition by dual-energy x-ray absorptiometry (DEXA), glucose tolerance by intravenous glucose tolerance test (IVGTT), and insulin sensitivity by hyperinsulinemic euglycemic clamp in nonanesthesized rats. Plasma leptin concentrations were also measured. Body weight increased after 4 weeks in virgin CAF rats ( P
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2003.09.025