Expression of E-cadherin, and CD44s and CD44v6 and its association with prognosis in head and neck cancer

Objectives: In the current study, the expression of E-cadherin, CD44s, and CD44v6 has been noted as markers for tumor metastasis and prognosis in several tumors, so we examined whether or not E-cadherin, CD44s, and CD44v6 are useful markers for evaluating the prognosis of mesopharyngeal cancer patie...

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Bibliographic Details
Published in:Auris, nasus, larynx nasus, larynx, 2004-03, Vol.31 (1), p.35-41
Main Authors: Kawano, Toshirou, Nakamura, Yoshiyasu, Yanoma, Shunsuke, Kubota, Akira, Furukawa, Madoka, Miyagi, Youhei, Tsukuda, Mamoru
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - metabolism
Cadherins - metabolism
CD44 variants
Cell Adhesion
E-cadherin
Female
Glycoproteins - metabolism
Head and neck cancer
Head and Neck Neoplasms - metabolism
Head and Neck Neoplasms - mortality
Head and Neck Neoplasms - pathology
Humans
Hyaluronan Receptors - metabolism
Immunohistochemistry
Male
Middle Aged
Pharyngeal Neoplasms - metabolism
Pharyngeal Neoplasms - mortality
Pharyngeal Neoplasms - pathology
Prognosis
Regression Analysis
Survival Rate
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Summary:Objectives: In the current study, the expression of E-cadherin, CD44s, and CD44v6 has been noted as markers for tumor metastasis and prognosis in several tumors, so we examined whether or not E-cadherin, CD44s, and CD44v6 are useful markers for evaluating the prognosis of mesopharyngeal cancer patients. Methods: The expression of E-cadherin, CD44s, and CD44v6, was evaluated immunohistochemically using monoclonal antibodies against epitopes of standard and variant proteins, in paraffin-embedded mesopharyngeal cancer tissues from 57 patients who had received curative therapy. Results: Tumor tissues from 47 (82.5%) patients showed positive immunoreactivity with monoclonal antibody against E-cadherin, 43 (75.4%) patients showed positive expression with CD44, and 45 (78.9%) patients showed positive expression with CD44v6. The expression of CD44v6 was slightly correlated with tumor volume, and lymph node metastasis, and stage classification ( P>0.05). However, there was no significant correlation between the expression of E-cadherin, CD44s and CD44v6 and clinicopathological characteristics. Concerning the prognosis, the survival period of patients with CD44s positive tumors was shorter than that of patients with CD44s negative tumors (18.2% versus 52.1%, 5-year survival, P
ISSN:0385-8146
1879-1476
DOI:10.1016/j.anl.2003.09.005