Dynamic intracoronary thrombosis does not cause significant downstream platelet embolization

A mural intracoronary thrombus is a potential source of platelet emboli that may obstruct downstream microvessels, but this phenomenon has not been characterized. The present study aimed to assess the magnitude of myocardial platelet accumulation downstream of a mural intracoronary thrombus and its...

Full description

Saved in:
Bibliographic Details
Published in:Cardiovascular research 2000-08, Vol.47 (2), p.265-273
Main Authors: BARRABES, J. A, GARCIA-DORADO, D, SORIANO, B, SOLARES, J, PUIGFEL, Y, TROBO, L, GARCIA-LAFUENTE, A, SOLER-SOLER, J
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Aspirin - therapeutic use
Biological and medical sciences
Cardiology. Vascular system
Coronary heart disease
Coronary Thrombosis - blood
Coronary Thrombosis - drug therapy
Coronary Thrombosis - pathology
Disease Models, Animal
Female
Heart
Male
Medical sciences
Myocardial Infarction - metabolism
Myocardial Infarction - pathology
Myocardium - metabolism
Myocardium - pathology
Perfusion
Peroxidase - metabolism
Platelet Aggregation - drug effects
Platelet Aggregation Inhibitors - therapeutic use
Random Allocation
Swine
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A mural intracoronary thrombus is a potential source of platelet emboli that may obstruct downstream microvessels, but this phenomenon has not been characterized. The present study aimed to assess the magnitude of myocardial platelet accumulation downstream of a mural intracoronary thrombus and its modification by a concomitant transient coronary occlusion (OC) or by treatment with aspirin. The myocardial content of 99mTc-labelled platelets was analyzed in 26 pigs submitted to intimal injury of the left anterior descending coronary artery (LAD) followed by no intervention (n=6), 25-min OC (n=6), or 48-min OC preceded (n=8) or not (n=6) by intravenous administration of 250 mg aspirin. After 2 h, 24 animals had had 12+/-1 cyclic flow reductions (CFRs) reflecting dynamic LAD thrombosis. Myocardial platelet content in the inferior region was similar among groups. Platelet content in the LAD region was not significantly different to that in the inferior region (129+/-19%, P=NS) in the no intervention group, but was increased following OC (172+/-20 and 312+/-71% after 25- and 48-min OC, respectively, P
ISSN:0008-6363
1755-3245
DOI:10.1016/S0008-6363(00)00110-3