The biphasic expression of IMP/Vg1-RBP is conserved between vertebrates and Drosophila

The human IGF-II mRNA-binding proteins (IMPs) 1–3, and their Xenopus homologue Vg1 RNA-binding protein (Vg1-RBP) are RNA-binding proteins implicated in mRNA localization and translational control in vertebrate development. We have sequenced the Drosophila homologue (dIMP) of these genes, and examine...

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Bibliographic Details
Published in:Mechanisms of development 2000-08, Vol.96 (1), p.129-132
Main Authors: Nielsen, Jacob, Cilius Nielsen, Finn, Kragh Jakobsen, Rasmus, Christiansen, Jan
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Biphasic expression
Central nervous system
Drosophila - embryology
Drosophila Proteins
Expressed Sequence Tags
In Situ Hybridization
K-homology domain
Molecular Sequence Data
Phylogeny
Protein Structure, Tertiary
RNA localization
RNA-binding proteins
RNA-Binding Proteins - biosynthesis
RNA-Binding Proteins - chemistry
RNA-Binding Proteins - metabolism
Sequence Homology, Amino Acid
Time Factors
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Summary:The human IGF-II mRNA-binding proteins (IMPs) 1–3, and their Xenopus homologue Vg1 RNA-binding protein (Vg1-RBP) are RNA-binding proteins implicated in mRNA localization and translational control in vertebrate development. We have sequenced the Drosophila homologue (dIMP) of these genes, and examined its expression pattern in Drosophila embryos by in situ hybridization. The study shows that dIMP exhibits a biphasic expression pattern. In the early stages of development, a maternal pool of dIMP mRNA is evenly distributed in the embryo and degraded by the end of stage 4. Expression reappears in the developing central nervous system, where dIMP is expressed throughout neurogenesis. In addition, dIMP is present in the pole cells.
ISSN:0925-4773
1872-6356
DOI:10.1016/S0925-4773(00)00383-X