Depletion of Tissue Angiotensin-Converting Enzyme Differentially Influences the Intrarenal and Urinary Expression of Angiotensin Peptides

ABSTRACT—The relative contribution of circulating versus tissue renin-angiotensin systems to the tissue expression of angiotensin peptides in the kidney remains unresolved. To address this issue, intrarenal and urinary levels of the peptide products of the renin-angiotensin system were assessed in a...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2004-04, Vol.43 (4), p.849-853
Main Authors: Modrall, J Gregory, Sadjadi, Javid, Brosnihan, K Bridget, Gallagher, Patricia E, Yu, Chun-hua, Kramer, Gerald L, Bernstein, Kenneth E, Chappell, Mark C
Format: Article
Language:English
Subjects:
Angiotensin I - analysis
Angiotensin I - biosynthesis
Angiotensin I - blood
Angiotensin I - genetics
Angiotensin II - analysis
Angiotensin II - biosynthesis
Angiotensin II - blood
Angiotensin II - genetics
Animals
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Carboxypeptidases - biosynthesis
Carboxypeptidases - genetics
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Diuresis
Endocrine kidney. Renin-angiotensin-aldosterone system
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Hypotension - genetics
Hypotension - metabolism
Kidney - metabolism
Medical sciences
Mice
Mice, Knockout
Organ Specificity
Peptide Fragments - analysis
Peptide Fragments - biosynthesis
Peptide Fragments - blood
Peptide Fragments - genetics
Peptidyl-Dipeptidase A - deficiency
Peptidyl-Dipeptidase A - genetics
Polyuria - genetics
Polyuria - metabolism
Renin-Angiotensin System - physiology
RNA, Messenger - biosynthesis
Vertebrates: endocrinology
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Summary:ABSTRACT—The relative contribution of circulating versus tissue renin-angiotensin systems to the tissue expression of angiotensin peptides in the kidney remains unresolved. To address this issue, intrarenal and urinary levels of the peptide products of the renin-angiotensin system were assessed in a tissue angiotensin-converting enzyme knockout (tis ACE) mouse model. Systolic blood pressure was significantly lower (64.6±3.6 versus 81.4±4.5 mm Hg; P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.0000121462.27393.f6