Association of humans leucocitary antigens with humoral nonresponsive to hepatitis B vaccine in chronic hemodialysis patients

• Published in: Revista da Sociedade Brasileira de Medicina Tropical 2004-01, Vol.37 (1), p.15-17
• Main Authors: de Sousa Júnior, Joaquim Xavier, de Monte Neto, José Tibúrcio, de Castro, José Adail Fonseca, de Andrade, Hélida Monteiro, do Monte, Semiramis Jamil Hadad
• Format: Article
• Language: eng ; por
• Subjects: Epitopes; Hepatitis; Hepatitis B - prevention & control; Hepatitis B Antibodies - biosynthesis; Hepatitis B Antibodies - blood; Hepatitis B Surface Antigens - administration & dosage; Hepatitis B Surface Antigens - immunology; Hepatitis B Vaccines - immunology; HLA Antigens - immunology; HLA-DQ Antigens - immunology; HLA-DR Antigens - immunology; Humans; Kidney Failure, Chronic - therapy; Phenotype; Renal Dialysis - adverse effects; Vaccines
• ISSN: 0037-8682; 1678-9849
• DOI: 10.1590/S0037-86822004000100004

Vaccination using surface antigen from hepatitis B virus has not been successfully responded by hemodialysis patients. The present study was aimed at assessing a possible relationship between human leukocyte antigens and the low production of protective antibodies (anti-HbS) against the surface antigen from hepatitis B by patients with chronic renal failure submitted to hemodialysis programs. The antigens HLA-DR and HLA-DQ were identified in 76 hemodialysis patients through classic microlymphotoxicity. Our results showed that 34.2% of the patients were non-responsive to the vaccine VHB. The most frequent HLA specificity were: HLA-DR3, DR-7 and DQ2 with a significant association for HLA-DR3 (p=0.0025; OR 5.1; IC 95% 1.36-19.10). Such data suggest an association between genes from HLA class II antigens and the humoral non-response to the vaccine VHB.