Optical glucose sensing in biological fluids: an overview

Recent technological advancements in the photonics industry have led to a resurgence of interest in optical glucose sensing and to realistic progress toward the development of an optical glucose sensor. Such a sensor has the potential to significantly improve the quality of life for the estimated 16...

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Bibliographic Details
Published in:Journal of Biomedical Optics 2000-01, Vol.5 (1), p.5-16
Main Authors: McNichols, Roger J, Cote´, Gerard L
Format: Article
Language:English
Subjects:
Absorption spectroscopy
Body fluids
Body Fluids - chemistry
Calibration
Fluorescence
Glucose - analysis
glucose sensing
Humans
infrared absorption
Optical data processing
Optical sensors
Optics and Photonics
Polarimeters
polarimetry raman spectroscopy
Raman spectroscopy
Spectrum Analysis - methods
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Summary:Recent technological advancements in the photonics industry have led to a resurgence of interest in optical glucose sensing and to realistic progress toward the development of an optical glucose sensor. Such a sensor has the potential to significantly improve the quality of life for the estimated 16 million diabetics in this country by making routine glucose measurements more convenient. Currently over 100 small companies and universities are working to develop noninvasive or minimally invasive glucose sensing technologies, and optical methods play a large role in these efforts. This article reviews many of the recent advances in optical glucose sensing including optical absorption spectroscopy, polarimetry, Raman spectroscopy, and fluorescent glucose sensing. In addition a review of calibration and data processing methods useful for optical techniques is presented. ©
ISSN:1083-3668
1560-2281
DOI:10.1117/1.429962