CD154 polymorphism in Spanish populations. Differences in the allelic distribution between Canary Islanders and Peninsulars

The CD154 gene contains a dinucleotide repeat (CA)n in the 3′ untranslated region. Allelic distribution in Spanish populations from two areas with different genetic background, the Canary Islands and Peninsula, are described. Seven alleles with different allelic distribution between the two groups,...

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Bibliographic Details
Published in:European journal of immunogenetics 2000-06, Vol.27 (3), p.141-144
Main Authors: Citores, M. J., Pérez-Aciego, P., Rodríguez-Gallego, C., Contreras-Martín, B., García-Laorden, I., Durántez, A.
Format: Article
Language:English
Subjects:
3' Untranslated Regions - genetics
Alleles
Canary Is
CD154 antigen
CD154 gene
CD40 Ligand
Dinucleotide Repeats - genetics
Electrophoresis
Female
Gene Frequency
Genetic Markers - genetics
Genetic Markers - immunology
Humans
Male
Membrane Glycoproteins - blood
Membrane Glycoproteins - genetics
Membrane Glycoproteins - immunology
Polymorphism, Genetic - genetics
Polymorphism, Genetic - immunology
Spain
Spain - epidemiology
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Description
Summary:The CD154 gene contains a dinucleotide repeat (CA)n in the 3′ untranslated region. Allelic distribution in Spanish populations from two areas with different genetic background, the Canary Islands and Peninsula, are described. Seven alleles with different allelic distribution between the two groups, were found. This represents a highly polymorphic marker, useful for genetic studies on a critical molecule in immunity.
ISSN:0960-7420
1365-2370
DOI:10.1046/j.1365-2370.2000.00220.x