Cyclonellin, a New Cyclic Octapeptide from the Marine Sponge Axinella carteri

Cyclonellin (1), a new cyclic octapeptide, was isolated from an aqueous extract of the marine sponge Axinella carteri. Its structure was elucidated by interpretation of NMR spectral data of the intact compound and N-terminal Edman sequencing of linear peptide fragments obtained by partial hydrolysis...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2004-03, Vol.67 (3), p.441-444
Main Authors: Milanowski, Dennis J, Rashid, Mohammad A, Gustafson, Kirk R, O'Keefe, Barry R, Nawrocki, Joseph P, Pannell, Lewis K, Boyd, Michael R
Format: Article
Language:English
Subjects:
Animals
Axinella carteri
Biological and medical sciences
Drug Screening Assays, Antitumor
General pharmacology
Humans
Marine
Medical sciences
Micronesia
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pacific Ocean
Peptides, Cyclic - chemistry
Peptides, Cyclic - isolation & purification
Peptides, Cyclic - pharmacology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Porifera - chemistry
Tumor Cells, Cultured
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Summary:Cyclonellin (1), a new cyclic octapeptide, was isolated from an aqueous extract of the marine sponge Axinella carteri. Its structure was elucidated by interpretation of NMR spectral data of the intact compound and N-terminal Edman sequencing of linear peptide fragments obtained by partial hydrolysis of 1. The absolute configurations of the constituent amino acids were determined by acid hydrolysis, derivitization with FDAA, and LC-MS analyses.
ISSN:0163-3864
1520-6025
DOI:10.1021/np030336x