Phenolic metabolites of Dalea versicolor that enhance antibiotic activity against model pathogenic bacteria

A new flavonoid (1) was isolated from organic extracts of Dalea versicolor, along with six known phenolic compounds (2-7). The structures of the seven compounds were determined by NMR and HRMS methods. These compounds were evaluated for direct activity against a variety of organisms in vitro, includ...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2004-03, Vol.67 (3), p.481-484
Main Authors: Belofsky, G, Percivill, D, Lewis, K, Tegos, G.P, Ekart, J
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Arizona
Bacillus cereus
Bacillus cereus - drug effects
Biological and medical sciences
Dalea versicolor
Fabaceae - chemistry
Flavonoids - chemistry
Flavonoids - isolation & purification
Flavonoids - pharmacology
General pharmacology
Medical sciences
Microbial Sensitivity Tests
Models, Biological
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phenols - chemistry
Phenols - isolation & purification
Phenols - pharmacology
Plants, Medicinal - chemistry
Pterocarpans - chemistry
Spectrometry, Mass, Electrospray Ionization
Staphylococcus aureus
Staphylococcus aureus - drug effects
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Summary:A new flavonoid (1) was isolated from organic extracts of Dalea versicolor, along with six known phenolic compounds (2-7). The structures of the seven compounds were determined by NMR and HRMS methods. These compounds were evaluated for direct activity against a variety of organisms in vitro, including the Gram-positive bacteria Staphylococcus aureus and Bacillus cereus. In addition, the compounds were evaluated for their ability to potentiate the activity of known antimicrobials through inhibition of multidrug-resistance (MDR) pumps. Compounds 1, 2, 4, and 7 exhibited direct or synergistic activity toward the human pathogen S. aureus and the opportunistic pathogen B. cereus. Compounds 4 and 7 were also found to potentiate the activity of berberine and of prescribed antibiotics, with 4 demonstrating a mode of action consistent with inhibition of the NorA MDR efflux pump in S. aureus.
ISSN:0163-3864
1520-6025
DOI:10.1021/np030409c