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Expression of mineralocorticoid and glucocorticoid receptor mRNA in the human hippocampus
The genomic effects of corticosteroids in the brain are mediated through two receptors with a high affinity for cortisol: the glucocorticoid and mineralocorticoid receptor (GR/MR). We used competitive reverse transcription-polymerase chain reaction to quantify the amount of MR and GR mRNA in hippoca...
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| Published in: | Neuroscience letters 2000-08, Vol.290 (2), p.121-124 |
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| Main Authors: | , , , , , |
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| cites | cdi_FETCH-LOGICAL-c539t-976b5d924328f66e0714375bf48f0f2343c3de648eedd829fe4f53b5836c06193 |
| container_end_page | 124 |
| container_issue | 2 |
| container_start_page | 121 |
| container_title | Neuroscience letters |
| container_volume | 290 |
| creator | Watzka, Matthias Beyenburg, Stefan Blümcke, Ingmar Elger, Christian E Bidlingmaier, Frank Stoffel-Wagner, Birgit |
| description | The genomic effects of corticosteroids in the brain are mediated through two receptors with a high affinity for cortisol: the glucocorticoid and mineralocorticoid receptor (GR/MR). We used competitive reverse transcription-polymerase chain reaction to quantify the amount of MR and GR mRNA in hippocampal tissue obtained from patients with temporal lobe epilepsy. MR and GR mRNA were expressed at approximately the same levels as in tissues known for high glucocorticoid/mineralocorticoid sensitivity, i.e. liver or kidney. MR mRNA concentrations were significantly higher in the hippocampus of women (0.24±0.04 aU, arbitrary units; mean±SEM) than in men (0.14±0.01 aU,
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| doi_str_mv | 10.1016/S0304-3940(00)01325-2 |
| format | article |
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| ispartof | Neuroscience letters, 2000-08, Vol.290 (2), p.121-124 |
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| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Adolescent Adult Age Factors Biochemistry and metabolism Biological and medical sciences Central nervous system Child Corticosteroid receptors Epilepsy Female Fundamental and applied biological sciences. Psychology Glucocorticoids - metabolism Hippocampus Hippocampus - cytology Hippocampus - metabolism Human Humans Male Receptors, Glucocorticoid - genetics Receptors, Mineralocorticoid - genetics RNA, Messenger - metabolism Sex difference Sex Factors Vertebrates: nervous system and sense organs |
| title | Expression of mineralocorticoid and glucocorticoid receptor mRNA in the human hippocampus |
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