New Cytotoxic Steroids from the Indian Ocean Sponge Axinella cf. bidderi

Four new sterols have been isolated from the marine sponge Axinella cf. bidderi, 17alpha-hydroxy-22,23-epoxy-24-methylcholest-5-en-3beta-ol (1) and 17alpha-hydroxy-22,23-epoxycholest-5-en-3beta-ol (2), together with 3 and 4, which possess respectively the cholestene and the cholestane skeleton with...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2004-03, Vol.67 (3), p.491-494
Main Authors: FUNEL, Corinne, BERRUé, Fabrice, ROUSSAKIS, Christos, FERNANDEZ RODRIGUEZ, Rogelio, AMADE, Philippe
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Axinella
Axinella bidderi
Axinellidae
Cholestenes - chemistry
Cholestenes - isolation & purification
Cholestenes - pharmacology
Drug Screening Assays, Antitumor
Halichondrida
Humans
Indian Ocean
Marine
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Porifera - chemistry
Stereoisomerism
Tumor Cells, Cultured
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Summary:Four new sterols have been isolated from the marine sponge Axinella cf. bidderi, 17alpha-hydroxy-22,23-epoxy-24-methylcholest-5-en-3beta-ol (1) and 17alpha-hydroxy-22,23-epoxycholest-5-en-3beta-ol (2), together with 3 and 4, which possess respectively the cholestene and the cholestane skeleton with a cyclic enol ether linkage between C-18 and C-22. The structures were elucidated using spectroscopic data. The in vitro activity was evaluated against prostate, ovary, pancreas, colon, and lung cell lines.
ISSN:0163-3864
1520-6025
DOI:10.1021/np034021t