Scleritodermin A, a Cytotoxic Cyclic Peptide from the Lithistid Sponge Scleritoderma nodosum

The lithistid sponge Scleritoderma nodosum contains a new cyclic peptide, scleritodermin A (1), the structure of which incorporates l-proline, l-serine, and keto-allo-isoleucine units as well as a novel conjugated thiazole moiety (ACT) and O-methyl-N-sulfoserine. Scleritodermin A (1) inhibited tubul...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2004-03, Vol.67 (3), p.475-478
Main Authors: SCHMIDT, Eric W., RAVENTOS-SUAREZ, Carmen, BIFANO, Marc, MENENDEZ, Ana T., FAIRCHILD, Craig R., FAULKNER, D. John
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents
Biological and medical sciences
Brain - drug effects
Cattle
Cell Cycle - drug effects
Cell Line, Tumor
Drug Screening Assays, Antitumor
Female
General pharmacology
Humans
Lithistida
Medical sciences
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Oceans and Seas
Peptides, Cyclic - chemistry
Peptides, Cyclic - isolation & purification
Peptides, Cyclic - pharmacology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Porifera - chemistry
Scleritoderma nodosum
Tubulin Modulators
Tumor Cells, Cultured
Vinblastine - pharmacology
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Summary:The lithistid sponge Scleritoderma nodosum contains a new cyclic peptide, scleritodermin A (1), the structure of which incorporates l-proline, l-serine, and keto-allo-isoleucine units as well as a novel conjugated thiazole moiety (ACT) and O-methyl-N-sulfoserine. Scleritodermin A (1) inhibited tubulin polymerization and showed significant in vitro cytotoxicity against human tumor cell lines.
ISSN:0163-3864
1520-6025
DOI:10.1021/np034035z