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Scleritodermin A, a Cytotoxic Cyclic Peptide from the Lithistid Sponge Scleritoderma nodosum

The lithistid sponge Scleritoderma nodosum contains a new cyclic peptide, scleritodermin A (1), the structure of which incorporates l-proline, l-serine, and keto-allo-isoleucine units as well as a novel conjugated thiazole moiety (ACT) and O-methyl-N-sulfoserine. Scleritodermin A (1) inhibited tubul...

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Published in:	Journal of natural products (Washington, D.C.) D.C.), 2004-03, Vol.67 (3), p.475-478
Main Authors:	SCHMIDT, Eric W., RAVENTOS-SUAREZ, Carmen, BIFANO, Marc, MENENDEZ, Ana T., FAIRCHILD, Craig R., FAULKNER, D. John
Format:	Article
Language:	English
Subjects:	Animals Antineoplastic Agents Biological and medical sciences Brain - drug effects Cattle Cell Cycle - drug effects Cell Line, Tumor Drug Screening Assays, Antitumor Female General pharmacology Humans Lithistida Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oceans and Seas Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera - chemistry Scleritoderma nodosum Tubulin Modulators Tumor Cells, Cultured Vinblastine - pharmacology
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container_end_page	478
container_issue	3
container_start_page	475
container_title	Journal of natural products (Washington, D.C.)
container_volume	67
creator	SCHMIDT, Eric W. RAVENTOS-SUAREZ, Carmen BIFANO, Marc MENENDEZ, Ana T. FAIRCHILD, Craig R. FAULKNER, D. John
description	The lithistid sponge Scleritoderma nodosum contains a new cyclic peptide, scleritodermin A (1), the structure of which incorporates l-proline, l-serine, and keto-allo-isoleucine units as well as a novel conjugated thiazole moiety (ACT) and O-methyl-N-sulfoserine. Scleritodermin A (1) inhibited tubulin polymerization and showed significant in vitro cytotoxicity against human tumor cell lines.
doi_str_mv	10.1021/np034035z
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source	American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects	Animals Antineoplastic Agents Biological and medical sciences Brain - drug effects Cattle Cell Cycle - drug effects Cell Line, Tumor Drug Screening Assays, Antitumor Female General pharmacology Humans Lithistida Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oceans and Seas Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera - chemistry Scleritoderma nodosum Tubulin Modulators Tumor Cells, Cultured Vinblastine - pharmacology
title	Scleritodermin A, a Cytotoxic Cyclic Peptide from the Lithistid Sponge Scleritoderma nodosum
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