Production of tumor necrosis factor in cells of hibernating ground squirrels Citellus Undulatus during annual cycle

TNF production has been studied in peritoneal macrophages and splenic T cells of Arctic Yakutian ground squirrel ( Citellus Undulatus Pallas) in hibernating and awake animals in winter and in prehibernating autumn as well as in active euthermic spring-summer animals. A high level of TNF production i...

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Bibliographic Details
Published in:Life sciences (1973) 2000, Vol.67 (9), p.1073-1080
Main Authors: Novoselova, Elena G., Kolaeva, Stella G., Makar, Vera R., Agaphonova, Tatiyna A.
Format: Article
Language:English
Subjects:
Animals
Concanavalin A - pharmacology
Female
Hibernating squirrels
Hibernation - immunology
Hibernation - physiology
Lymphocyte Activation - drug effects
Lymphocyte Activation - physiology
Macrophage Activation - physiology
Macrophages
Macrophages, Peritoneal - immunology
Macrophages, Peritoneal - metabolism
Male
Proliferation
Sciuridae - immunology
Sciuridae - metabolism
Sciuridae - physiology
Seasons
T cells
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
TNF production
Tumor Necrosis Factor-alpha - biosynthesis
Tumor Necrosis Factor-alpha - immunology
Tumor Necrosis Factor-alpha - metabolism
Wakefulness - physiology
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Summary:TNF production has been studied in peritoneal macrophages and splenic T cells of Arctic Yakutian ground squirrel ( Citellus Undulatus Pallas) in hibernating and awake animals in winter and in prehibernating autumn as well as in active euthermic spring-summer animals. A high level of TNF production in macrophages of ground squirrel is observed over the active period and during arousals in winter. There are no significant season variations in TNF production in splenic T lymphocytes of ground squirrels. This suggests the major role of activated macrophages in the arousals of hibernating animals. T lymphocyte proliferation in ground squirrels in the active period is higher than in winter, and the most significant seasonal variations are found in T cell mitogenic response, which increases in spring-summer period. Evidence is presented that functional activity of macrophages of squirrel in autumn has much in common with that in winter rather than in spring-summer period.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(00)00698-6