Vaginal fetal fibronectin measurements from 8 to 22 weeks' gestation and subsequent spontaneous preterm birth

Objective: We sought to determine the range of fetal fibronectin values in the vagina from 8 to 22 weeks' gestation, the factors associated with both low and high values, and whether high values are associated with gestational age at birth. Study Design: Vaginal fetal fibronectin was quantitati...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2000-08, Vol.183 (2), p.469-475
Main Authors: Goldenberg, Robert L., Klebanoff, Mark, Carey, J.Christopher, MacPherson, Cora, Leveno, Kenneth J., Moawad, Atef H., Sibai, Baha, Heine, R.P., Ernest, J.M., Dombrowski, Mitchell P., Miodovnik, Menachem, Wapner, Ronald J., Iams, Jay D., Langer, Oded, O'Sullivan, Mary J., Roberts, James M.
Format: Article
Language:English
Subjects:
African Continental Ancestry Group
bacterial vaginosis
Cohort Studies
Female
fetal fibronectin
Fetus - metabolism
Fibronectins - metabolism
Gestational Age
Humans
Obstetric Labor, Premature
Pregnancy
Pregnancy Complications, Infectious - metabolism
Preterm birth
Prospective Studies
Risk Factors
Trichomonas vaginalis
Vagina - metabolism
Vaginosis, Bacterial - metabolism
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Summary:Objective: We sought to determine the range of fetal fibronectin values in the vagina from 8 to 22 weeks' gestation, the factors associated with both low and high values, and whether high values are associated with gestational age at birth. Study Design: Vaginal fetal fibronectin was quantitatively determined in a prospective cohort study of 13,360 women being evaluated for participation in the National Institute of Child Health and Human Development Maternal-Fetal Medicine Unit treatment trials for bacterial vaginosis and Trichomonas vaginalis. Fetal fibronectin values were correlated with gestational age at screening, race, the presence of bacterial vaginosis and Trichomonas vaginalis, and gestational age at delivery. Results: Vaginal fetal fibronectin values at each gestational age ranged from unmeasurable to >1000 ng/mL, with median values always being
ISSN:0002-9378
1097-6868
DOI:10.1067/mob.2000.106073