Diagnostic performance of arginase activity in colorectal cancer

Arginase activity was measured in serum and biopsy from healthy individuals and colorectal cancer patients. Arginase activity in tumor samples (87 +/- 7.7 U/g tissue) was significantly higher than in controls (40.7 +/- 3.3 U/g tissue). However, serum arginase activity did not show any significant ch...

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Bibliographic Details
Published in:Clinical and experimental medicine 2002-05, Vol.2 (1), p.53-57
Main Authors: RANGEL, M. Del, GONZALEZ-POLO, R. A, CARO, A, DEL AMO, E, PALOMO, L, HERNANDEZ, E, SOLER, G, FUENTES, J. M
Format: Article
Language:English
Subjects:
Arginase - blood
Biological and medical sciences
Biological Assay
Biomarkers, Tumor
Biopsy
Carcinoma - diagnosis
Carcinoma - metabolism
Colorectal cancer
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - metabolism
Diagnostic tests
Enzyme Stability
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Medical sciences
Proteins
Sensitivity and Specificity
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
Urea - metabolism
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Summary:Arginase activity was measured in serum and biopsy from healthy individuals and colorectal cancer patients. Arginase activity in tumor samples (87 +/- 7.7 U/g tissue) was significantly higher than in controls (40.7 +/- 3.3 U/g tissue). However, serum arginase activity did not show any significant change in both groups. Finally, the micromethod used to quantify arginase activity in this study is superior to other methods because it has increased sensitivity, requires less sample, and is less time-consuming. Arginase differences are significant, according to the t-test (P
ISSN:1591-8890
1591-9528
DOI:10.1007/s102380200007