Effects of quinupristin/dalfopristin on vasomotor tone in the intact peripheral microcirculation

The purpose of this study was to determine whether quinupristin/dalfopristin modulates vasomotor tone in the intact peripheral microcirculation. Using intravital microscopy, we found that superfusion of quinupristin/dalfopristin (120 mg/L) on the intact hamster cheek pouch microcirculation had no si...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2002-06, Vol.49 (6), p.1027-1030
Main Authors: Tsueshita, Takaya, Gandhi, Salil, Rubinstein, Israel
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cheek - blood supply
Cricetinae
Drug Therapy, Combination - pharmacology
Drug toxicity and drugs side effects treatment
In Vitro Techniques
Male
Medical sciences
Mesocricetus
Microcirculation - drug effects
Microcirculation - physiology
Pharmacology. Drug treatments
Toxicity: cardiovascular system
Vasodilation - drug effects
Vasodilation - physiology
Vasodilator Agents - pharmacology
Vasomotor System - drug effects
Vasomotor System - physiology
Virginiamycin - pharmacology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The purpose of this study was to determine whether quinupristin/dalfopristin modulates vasomotor tone in the intact peripheral microcirculation. Using intravital microscopy, we found that superfusion of quinupristin/dalfopristin (120 mg/L) on the intact hamster cheek pouch microcirculation had no significant effects on arteriolar diameter. In addition, superfusion of quinupristin/dalfopristin (120 mg/L) had no significant effects on vasodilation evoked by bradykinin and acetylcholine, two endothelium-dependent agonists, or by vasoactive intestinal peptide, an endothelium-independent agonist, on to the cheek pouch. Collectively, these data indicate that quinupristin/dalfopristin has no significant effects on vasomotor tone in the intact peripheral microcirculation.
ISSN:0305-7453
1460-2091
1460-2091
DOI:10.1093/jac/dkf051