Endogenous morphine

It is now well accepted that endogenous morphine is present in animals, both in invertebrates and vertebrates. It is a key signaling molecule that plays an important role in downregulating physiological responses, such as those in the immune system, including immune elements in the CNS. It has been...

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Bibliographic Details
Published in:Trends in Neurosciences 2000-09, Vol.23 (9), p.436-442
Main Authors: Stefano, George B., Goumon, Yannick, Casares, Federico, Cadet, Patrick, Fricchione, Gregory L., Rialas, Christos, Peter, Doris, Sonetti, Dario, Guarna, Massimo, Welters, Ingeborg D., Bianchi, Enrica
Format: Article
Language:English
Subjects:
Addiction
Analgesia
Animals
Biochemistry
Biological and medical sciences
Brain Chemistry - physiology
Dependence
Fundamental and applied biological sciences. Psychology
General aspects. Models. Methods
Hormones
Humans
Morphine
Morphine - metabolism
Nervous system
Neurology
Opiate-receptor
Opioid Peptides - metabolism
Opium
Receptors, Opioid - metabolism
Vertebrates: nervous system and sense organs
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Summary:It is now well accepted that endogenous morphine is present in animals, both in invertebrates and vertebrates. It is a key signaling molecule that plays an important role in downregulating physiological responses, such as those in the immune system, including immune elements in the CNS. It has been demonstrated that a specific μ-opiate-receptor subtype, μ3, mediates these downregulatory effects through release of NO. This article examines morphine as an endogenous signaling molecule, in terms of its role in neural and immune regulation.
ISSN:0166-2236
1878-108X
DOI:10.1016/S0166-2236(00)01611-8