High apoptotic activity and low epithelial cell proliferation with underexpression of p21(WAF1/CIP1) and p27Kip1 of mucinous carcinomas of the colorectum: comparison with well-differentiated type

We comparatively assessed 41 mucinous colorectal carcinomas (MUCs) and 620 non-MUC (well-, moderately, and poorly differentiated adenocarcinoma) cases for clinicopathologic findings; and 41 MUCs and 115 randomly selected non-MUCs also were studied for the following: (1) apoptotic activity and Ki-67...

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Bibliographic Details
Published in:American journal of clinical pathology 2002-06, Vol.117 (6), p.908-915
Main Authors: Akino, Fumiyuki, Mitomi, Hiroyuki, Nakamura, Takatoshi, Ohtani, Yoshimasa, Ichinoe, Masaaki, Okayasu, Isao
Format: Article
Language:English
Subjects:
Adenocarcinoma, Mucinous - genetics
Adenocarcinoma, Mucinous - metabolism
Adenocarcinoma, Mucinous - mortality
Adenocarcinoma, Mucinous - secondary
Adult
Aged
Aged, 80 and over
Apoptosis
Carrier Proteins - metabolism
Cell Division
Colorectal Neoplasms - genetics
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinase Inhibitor p27
Cyclins - metabolism
DNA Mutational Analysis
DNA, Neoplasm - analysis
Epithelial Cells - metabolism
Epithelial Cells - pathology
Female
Genes, ras
Humans
Immunoenzyme Techniques
Intracellular Signaling Peptides and Proteins
Ki-67 Antigen - metabolism
Male
Middle Aged
Polymerase Chain Reaction
Survival Analysis
Survival Rate
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Summary:We comparatively assessed 41 mucinous colorectal carcinomas (MUCs) and 620 non-MUC (well-, moderately, and poorly differentiated adenocarcinoma) cases for clinicopathologic findings; and 41 MUCs and 115 randomly selected non-MUCs also were studied for the following: (1) apoptotic activity and Ki-67 immunoreactivity; (2) immunohistochemical expression of p21(WAF1/CIP1), p27Kip1, p53, and bcl-2; and (3) c-Ki-ras mutations. The rates for lymph node involvement and peritoneal dissemination were higher in MUCs than in non-MUCs. Multivariate analysis showed MUCs to have a worse prognosis than well-differentiated adenocarcinomas. The Ki-67 labeling for MUCs was significantly lower than that for non-MUCs, whereas the apoptotic index was significantly higher than for the well-differentiated type. The labeling for p21(WAF1/CIP1) and p27Kip1 was lower in MUCs (2.7% and 35.3%, respectively) than in well-differentiated adenocarcinomas (4.2% and 48.6%, respectively). MUCs can be considered a different tumor from the well-differentiated type, with a poor prognosis owing to frequent lymph node metastasis and peritoneal dissemination, and characterized by high apoptotic and low proliferative activities associated with low p21(WAF1/CIP1) and p27Kip1 expression.
ISSN:0002-9173