Ki-67 and CEA expression as prognostic markers in Dukes' C colorectal cancer

This study investigated the relationship between clinicopathological or immunohistochemical factors and postoperative prognosis for Dukes' C colorectal cancer. Short-term survivors died from cancer within 2 years of surgery, whereas long-term survivors were disease-free for over 10 years. The g...

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Bibliographic Details
Published in:Cancer letters 2004-04, Vol.207 (1), p.109-115
Main Authors: Ishida, Hideyuki, Miwa, Hideaki, Tatsuta, Masayuki, Masutani, Seizo, Imamura, Hiroshi, Shimizu, Junzo, Ezumi, Koji, Kato, Hitoshi, Kawasaki, Takatoshi, Furukawa, Hiroshi, Kawakami, Hitoshi
Format: Article
Language:English
Subjects:
Age
Aged
Biomarkers, Tumor
Cancer therapies
Carcinoembryonic Antigen - biosynthesis
CEA
Cell Line, Tumor
Chemotherapy
Colon
Colorectal cancer
Colorectal Neoplasms - metabolism
Cytoplasm
Disease-Free Survival
Dukes' C colorectal cancer
Female
Gender
Humans
Immunohistochemistry
Ki-67 antigen
Ki-67 Antigen - biosynthesis
Lymphatic Metastasis
Male
Medical prognosis
Middle Aged
Mortality
Patients
Prognosis
Prognostic marker
Proteins
Surgery
Time Factors
Tumor Suppressor Protein p53 - biosynthesis
Tumors
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Summary:This study investigated the relationship between clinicopathological or immunohistochemical factors and postoperative prognosis for Dukes' C colorectal cancer. Short-term survivors died from cancer within 2 years of surgery, whereas long-term survivors were disease-free for over 10 years. The groups differed in Ki-67 antigen and CEA expression in colon cancer, and CEA expression in rectal cancer that was limited to the metastatic lymph nodes. The immunohistochemical scores were higher in short-term survivors. Our data suggest that the characteristics of metastatic lymph nodes are important as a predictor of the aggressiveness of tumor behavior and that the expression of Ki-67 antigen or CEA there may be a useful indicators of patients' survival in Dukes' C colorectal cancer.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2003.10.032