Attenuation of liver ischemia-reperfusion-induced atrial dysfunction by external pacing but not by isoproterenol

Remote ischemia-reperfusion detrimentally affects myocardial function by initially interfering with the rate of contraction. We investigated the usefulness of isoproterenol versus external electrical pacing in attenuating secondary functional damage of isolated Wistar rat atria. Atrial strips (n = 1...

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Bibliographic Details
Published in:Canadian journal of physiology and pharmacology 2004-01, Vol.82 (1), p.9-15
Main Authors: Ben-Abraham, Ron, Shapira, Itzhak, Szold, Amiki, Weinbroum, Avi A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Drugs
Electricity
Gastroenterology. Liver. Pancreas. Abdomen
Heart
Heart Atria - drug effects
Heart Atria - physiopathology
In Vitro Techniques
Isoproterenol - pharmacology
Isoproterenol - therapeutic use
Liver - blood supply
Liver - drug effects
Liver - physiopathology
Liver diseases
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Myocardial Contraction - drug effects
Myocardial Contraction - physiology
Other diseases. Semiology
Pacemaker, Artificial
Physiological aspects
Rats
Rats, Wistar
Reperfusion Injury - physiopathology
Reperfusion Injury - therapy
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Summary:Remote ischemia-reperfusion detrimentally affects myocardial function by initially interfering with the rate of contraction. We investigated the usefulness of isoproterenol versus external electrical pacing in attenuating secondary functional damage of isolated Wistar rat atria. Atrial strips (n = 10/group) were bathed within oxygenated Krebs-Henseleit solution that exited from isolated livers that had been either perfused normally (controls) or underwent no flow (ischemia) for 2 h. In addition to one noninterventional ischemia-exposed strip group, a second group was externally paced at a fixed rate (55 pulses·min -1 , 6 V) and a third "ischemia" group was treated with isoproterenol (0.1 mM), both interventions commencing upon the strips' exposure to the hepatic effluents. Control strips displayed unaltered contraction rate and systolic-generated tension during the 2-h exposure. Nontreated strips exposed to ischemic reperfusate experienced bradycardia compared with baseline values (7 ± 2 vs. 50 ± 12 beats·min -1 , p < 0.05), followed
ISSN:0008-4212
1205-7541
DOI:10.1139/y03-125