Intractable Eye Pain: Indication for Triptans

Management of pain is difficult in many eye diseases. Particularly in patients undergoing surgical procedures, postoperative intractable pain is a major concern and severely influences the patient's comfort. We present 13 patients (eight male, five female, mean age 36 years) in whom sumatriptan...

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Bibliographic Details
Published in:Cephalalgia 2002-04, Vol.22 (3), p.195-196
Main Authors: May, A, Gamulescu, MA, Bogdahn, U, Lohmann, CP
Format: Article
Language:English
Subjects:
Adult
Eye - drug effects
Eye pain
Female
Humans
Lasers, Excimer
Male
Middle Aged
Pain, Intractable - drug therapy
Pain, Postoperative - drug therapy
photorefractive keratectomy
Photorefractive Keratectomy - adverse effects
Photorefractive Keratectomy - statistics & numerical data
Pilot Projects
Prospective Studies
Serotonin Receptor Agonists - therapeutic use
sumatriptan
Sumatriptan - therapeutic use
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Summary:Management of pain is difficult in many eye diseases. Particularly in patients undergoing surgical procedures, postoperative intractable pain is a major concern and severely influences the patient's comfort. We present 13 patients (eight male, five female, mean age 36 years) in whom sumatriptan, a highly selective 5-HT1B/1D agonist that is normally used as a specific anti-migraine drug, was used for the treatment of pain following photorefractive keratectomy (PRK). In two patients both eyes were operated on different days, resulting in a total of 15 operated eyes. A positive clinical response was achieved in all patients. In particular, in four patients, who received a second dose prophylactically 4 h following the first dose and before the recurrence of pain, we achieved excellent efficacy and stable control of pain. Further controlled studies are needed to investigate the usefulness of 5-HT1B/1D agonists in painful eye conditions.
ISSN:0333-1024
1468-2982
DOI:10.1046/j.1468-2982.2002.00342.x